{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:59:35Z","timestamp":1777420775636,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Objective: To review the pharmacology, pharmacokinetics, efficacy, safety, dosing, and cost information of glecaprevir\/pibrentasvir in the treatment of hepatitis C virus (HCV). Data Sources: A literature search was conducted between September 2018 and July 2019 using PubMed and Google Scholar with the search terms glecaprevir, pibrentasvir, Mavyret, Maviret, and hepatitis C. Clinicaltrials.gov was searched using the same terms. References of published articles were assessed for additional information. Study Selection and Data Extraction: English-language preclinical and clinical studies on the chemistry, pharmacology, pharmacokinetics, safety, and efficacy of glecaprevir\/pibrentasvir were evaluated. Data Synthesis: Food and Drug Administration\u2013approved glecaprevir\/pibrentasvir is considered both safe and efficacious for the treatment of HCV genotypes 1 to 6 and in several patient populations, such as those with treatment-na\u00efve or treatment-experienced HCV; with or without compensated cirrhosis, HIV-1 coinfection, or renal impairment; post\u2013liver or post\u2013kidney transplant; and \u226512 years of age. Sustained virological response rates ranged from 83% to 100% in clinical trials, and safety outcomes appear similar to other guideline-recommended HCV treatment options. Relevance to Patient Care and Clinical Practice: This review discusses the pharmacological, efficacy, and safety data found in glecaprevir\/pibrentasvir clinical trials and relates this to guideline recommendations and the practical use of this medication for treatment of HCV. Conclusions: With HCV infection rates remaining elevated, it is important to have safe and efficacious treatment options. Glecaprevir\/pibrentasvir is a safe and efficacious guideline-recommended, 8-week treatment for HCV in several patient populations, with these populations likely growing in the near future given ongoing and future studies.<\/jats:p>","DOI":"10.1177\/1060028019877128","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T01:12:55Z","timestamp":1568941975000},"page":"262-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Glecaprevir\/Pibrentasvir: The First 8-Week, Pangenotypic HCV Treatment Regimen for Patients 12 Years of Age and Older"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-907X","authenticated-orcid":false,"given":"Jamie","family":"Huff","sequence":"first","affiliation":[{"name":"Shenandoah University, Winchester, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2351-056X","authenticated-orcid":false,"given":"Rebecca","family":"Andersen","sequence":"additional","affiliation":[{"name":"Shenandoah University, Winchester, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"bibr1-1060028019877128","volume-title":"Global Hepatitis Report, 2017","author":"World Health Organization","year":"2017"},{"key":"bibr3-1060028019877128","volume-title":"Hepatitis C","author":"Basit H","year":"2019"},{"key":"bibr6-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29671"},{"key":"bibr8-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30496-6"},{"key":"bibr9-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy220"},{"key":"bibr10-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702417"},{"key":"bibr11-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30341-8"},{"key":"bibr12-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30840"},{"key":"bibr13-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29081"},{"key":"bibr14-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30046"},{"key":"bibr16-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704053"},{"key":"bibr18-1060028019877128","volume-title":"Paper presented at: AASLD: The Liver Meeting\u00ae","author":"Brown RS"},{"key":"bibr19-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29541"},{"key":"bibr20-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.027"},{"key":"bibr24-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.039"},{"key":"bibr25-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.01.031"},{"key":"bibr26-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01249-18"},{"key":"bibr27-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"bibr28-1060028019877128","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-018-9873-y"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028019877128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028019877128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028019877128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:11Z","timestamp":1777374911000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/1060028019877128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1177\/1060028019877128"],"URL":"https:\/\/doi.org\/10.1177\/1060028019877128","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,19]]}}}