{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:06Z","timestamp":1777420806849,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Background: Self-reported penicillin allergies may be outdated or inaccurate, leading to the use of alternative antimicrobials that may be less effective, more toxic, and\/or more expensive. Although penicillin skin tests can provide accurate assessments of penicillin allergies, these procedures are not feasible at all institutions. Another solution is to conduct a detailed penicillin allergy interview (DPAI), which can potentially lead to optimization of antimicrobial therapy. Objective: The purpose of this study was to assess the impact of a pharmacist-driven DPAI protocol. The primary objective was to measure the number of patients requiring a change to their allergy profile following DPAI. Secondary objectives included characterizing allergy profile updates and measuring the number of recommendations to switch to a \u03b2-lactam agent, provider acceptance rate, and patient tolerance. Methods: Standardized pharmacist-driven DPAIs were conducted prospectively on adult patients admitted with a documented penicillin allergy. The allergy profile within the electronic health record (EHR) was updated and a recommendation to switch to noncarbapenem \u03b2-lactam therapy was made when indicated by a decision algorithm. Results: A total of 175 (37.5%) patients received a DPAI. Of these, 133 (76.0%) required a change to their allergy profile. Additionally, 135 (77.1%) patients interviewed were on antimicrobial therapy, with 42 (31.1%) meeting criteria to switch to noncarbapenem \u03b2-lactam therapy; of which 31 (73.8%) patients were successfully transitioned, with no signs or symptoms of intolerance. Conclusions and Relevance: Implementation of pharmacist-driven DPAIs can provide updated and corrected allergy information within the EHR, allowing for de-escalation and\/or optimization of antimicrobial therapy.<\/jats:p>","DOI":"10.1177\/1060028019884874","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T11:55:03Z","timestamp":1573214103000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Implementation of a Pharmacist-Driven Detailed Penicillin Allergy Interview"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-9434","authenticated-orcid":false,"given":"Katrina L.","family":"Mann","sequence":"first","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"bibr1-1060028019884874","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3791"},{"key":"bibr2-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.08.002"},{"key":"bibr3-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19283"},{"key":"bibr4-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy557"},{"key":"bibr5-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.18.2819"},{"key":"bibr6-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.9.8.722"},{"key":"bibr7-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01638.x"},{"key":"bibr8-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.01.006"},{"key":"bibr9-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"bibr10-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz082"},{"key":"bibr11-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.50"},{"key":"bibr12-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky575"},{"key":"bibr14-1060028019884874","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.82a.14111"},{"key":"bibr15-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw153"},{"key":"bibr16-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2498"},{"key":"bibr17-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1177\/0897190015587254"},{"key":"bibr18-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1111\/all.13168"},{"key":"bibr19-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.6510"},{"key":"bibr20-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2016.05.005"},{"key":"bibr21-1060028019884874","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150288"},{"key":"bibr22-1060028019884874","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx171"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028019884874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028019884874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028019884874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:15Z","timestamp":1777374915000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/1060028019884874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/1060028019884874"],"URL":"https:\/\/doi.org\/10.1177\/1060028019884874","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]}}}