{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:17Z","timestamp":1777420817925,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    Background: No previous studies exist examining 2 inhaled epoprostenol formulations in an acute respiratory distress syndrome (ARDS) patient population. Objective: The study aim was to evaluate a formulary conversion from inhaled Flolan to Veletri to determine the impact on effectiveness, safety, and cost in patients with ARDS. Methods: This was a single-center, retrospective, matched cohort observational study at a tertiary care academic medical center. Patients included were mechanically ventilated, adult patients with ARDS receiving inhaled Flolan or Veletri for \u22651 hour in the intensive care unit. Results: A total of 132 patients were included in the matched cohort. There was no difference detected in change in partial pressure of arterial O\n                    <jats:sub>2<\/jats:sub>\n                    \/fraction of inspired O\n                    <jats:sub>2<\/jats:sub>\n                    (PaO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    ) ratio after 1 hour of therapy between the inhaled Flolan and Veletri groups (27.2 \u00b1 46.2 vs 30 \u00b1 68 mm Hg, P = 0.78). Significant differences in secondary outcomes included incidence of hypotension (83% vs 95.5%, P = 0.04) and thrombocytopenia (9.1% vs 29.5%, P &lt; 0.01) in the inhaled Flolan and Veletri groups, respectively, with no difference in cost per duration of therapy ( P = 0.29). Conclusions and Relevance: There was no difference in the change in PaO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    ratio after 1 hour of therapy between inhaled Flolan and Veletri in an ARDS patient population. The formulary conversion from inhaled Flolan to Veletri was likely justified.\n                  <\/jats:p>","DOI":"10.1177\/1060028019888853","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T07:17:16Z","timestamp":1573802236000},"page":"434-441","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness, Safety, and Economic Comparison of Inhaled Epoprostenol Brands, Flolan and Veletri, in Acute Respiratory Distress Syndrome"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5992-7375","authenticated-orcid":false,"given":"Jaclyn M.","family":"Hawn","sequence":"first","affiliation":[{"name":"Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-0320","authenticated-orcid":false,"given":"Seth R.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Wanek","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manshi","family":"Li","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Duggal","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Torbic","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"bibr1-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2011.118398"},{"key":"bibr2-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"bibr3-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.06.032"},{"key":"bibr4-1060028019888853","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S28800"},{"key":"bibr5-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201703-0548ST"},{"key":"bibr6-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.6.860"},{"key":"bibr7-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015621308"},{"key":"bibr8-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630585"},{"key":"bibr9-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00097107"},{"key":"bibr10-1060028019888853","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015608865"},{"key":"bibr11-1060028019888853","unstructured":"Flolan [package insert]. Research Triangle Park, NC: GlaxoSmith Kline; 2016."},{"key":"bibr12-1060028019888853","unstructured":"Veletri [package insert]. 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