{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:48Z","timestamp":1777420848258,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Background: A vancomycin target of area under the curve to minimum inhibitory concentration (AUC:MIC) ratio \u2265400 is recommended for treatment of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Objective: To evaluate vancomycin total daily dose (TDD) achieving trough targets versus a calculated strategy achieving AUC targets based on body mass index (BMI). Methods: A retrospective cohort study was performed within a large hospital network. Patients with MRSA bacteremia were eligible if they received vancomycin with a steady-state trough (15-20 mg\/L). Cockcroft-Gault was used to estimate creatinine clearance, calculating vancomycin clearance and AUC. Patients were stratified by BMI (less than\/greater than 30 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ). The primary outcome was vancomycin TDD for the trough-based strategy compared with an AUC-dosing strategy. Results: A total of 119 patients were included, including 51 (42.9%) and 68 (57.1%) patients with high- and low-BMI, respectively. The TDD for trough-based dosing (2390.76 \u00b1 1224.59 mg) differed significantly from AUC-based dosing (1985.07 \u00b1 616.18 mg) across the cohort ( P = 0.0014). For patients with high BMI, there was a significant difference ( P &lt; 0.0001) in TDD between trough (2637.25 \u00b1 1327.89 mg) versus AUC (1918.71 \u00b1 625.89 mg) strategies. No difference in TDD between dosing strategies was observed among low-BMI patients. Across all patients, 46 (38.7%) experienced acute kidney injury (AKI); high-BMI patients experienced higher rates of AKI compared with low-BMI patients (54.9 vs 26.5%; P = 0.002). Conclusions and Relevance: An AUC-based dosing strategy may reduce vancomycin TDD required for MRSA bacteremia compared with trough-based dosing, particularly for patients with higher BMI.\n                  <\/jats:p>","DOI":"10.1177\/1060028019897100","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T02:18:00Z","timestamp":1577758680000},"page":"644-651","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of Vancomycin Area-Under-the-Curve Dosing Versus Trough Target\u2013Based Dosing in Obese and Nonobese Patients With Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Bacteremia"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-2042","authenticated-orcid":false,"given":"Jordan R.","family":"Covvey","sequence":"first","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Erickson","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"},{"name":"Delta Care Rx, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fiumara","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"},{"name":"St Anthony\u2019s Hospital, St Petersburg, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Mazzei","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"},{"name":"Louis A. Johnson VA Medical Center, Clarksburg, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Moszczenski","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"},{"name":"Christian Hospital, St Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Slipak","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branden D.","family":"Nemecek","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"},{"name":"University of Pittsburgh Medical Center\u2014Mercy Hospital, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"},{"name":"University of Pittsburgh Medical Center\u2014Mercy Hospital, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-8847","authenticated-orcid":false,"given":"Anthony J.","family":"Guarascio","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy, Pittsburgh, PA, USA"},{"name":"Allegheny General Hospital, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"bibr1-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1801-3"},{"key":"bibr2-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.10423"},{"key":"bibr3-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05022-11"},{"key":"bibr4-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14"},{"key":"bibr5-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146224."},{"key":"bibr6-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"bibr7-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1086\/600877"},{"key":"bibr8-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1638"},{"key":"bibr9-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01653-13"},{"key":"bibr10-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01293-17"},{"key":"bibr11-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1177\/0897190016642692"},{"key":"bibr12-1060028019897100","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110324"},{"key":"bibr13-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02490-16"},{"key":"bibr14-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv176"},{"key":"bibr15-1060028019897100","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp100410"},{"key":"bibr16-1060028019897100","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110214"},{"key":"bibr17-1060028019897100","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky310"},{"key":"bibr18-1060028019897100","unstructured":"Allegheny Health Network. 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