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The extraction period had no historical limit and spanned through April 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Evidence was compiled and summarized for the following medical conditions: Alzheimer disease, amyotrophic lateral sclerosis, autism, cancer and cancer-associated adverse effects, seizure disorders, human immunodeficiency virus, inflammatory bowel disease, multiple sclerosis (MS), nausea, pain, posttraumatic stress disorder, and hospice care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Patient Care and Clinical Practice:<\/jats:title>\n                    <jats:p>Based on identified data, the most robust evidence suggests that medical cannabis may be effective in the treatment of chemotherapy-induced nausea and vomiting, seizure disorders, MS-related spasticity, and pain (excluding diabetic neuropathy). Overall, the evidence is inconsistent and generally limited by poor quality. The large variation in cannabis-based products evaluated in studies limits the ability to make direct comparisons. Regardless of the product, a gradual dose titration was utilized in most studies. Cannabis-based therapies were typically well tolerated, with the most common adverse effects being dizziness, somnolence, dry mouth, nausea, and euphoria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>As more states authorize medical cannabis use, there is an increasing need for high-quality clinical evidence describing its efficacy and safety. This review is intended to serve as a reference for clinicians, so that the risks and realistic benefits of medical cannabis are better understood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1060028020930189","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T08:08:20Z","timestamp":1591085300000},"page":"1109-1143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Clinical Data for the Use of Cannabis-Based Treatments: A Comprehensive Review of the Literature"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-9300","authenticated-orcid":false,"given":"Shannon","family":"Inglet","sequence":"first","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradly","family":"Winter","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Yost","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Entringer","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Lian","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl","family":"Biksacky","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee D.","family":"Pitt","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Taylorsville, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"bibr1-1060028020930189","unstructured":"United States Drug Enforcement Administration. 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