{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:59:13Z","timestamp":1785358753621,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review the pharmacology, microbiology, efficacy, and safety of lefamulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A literature search was performed using PubMed and Google Scholar (2010 to end-April 2020) with the search terms BC-3781 and lefamulin. Other resources included abstracts presented at recent conferences, prescribing information, and the manufacturer\u2019s and Food and Drug Administration websites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>All relevant English-language articles of studies assessing the efficacy and safety of lefamulin were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Lefamulin is a pleuromutilin antibiotic with activity against Staphylococcus aureus, Streptococcus pneumoniae, and atypical bacteria. Lefamulin, given at the dose of 150 mg intravenously or 600 mg orally on an empty stomach every 12 hours for 5 to 7 days, was proven noninferior to moxifloxacin for the treatment of community-acquired bacterial pneumonia (CABP). Common adverse reactions include injection site reactions, hepatic enzyme elevation, gastrointestinal upset, hypokalemia, insomnia, and headache. Lefamulin is associated with QT prolongation, and concomitant use with CYP3A substrates that prolong the QT interval is contraindicated. Lefamulin may cause fetal harm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Patient Care and Clinical Practice:<\/jats:title>\n                    <jats:p>Lefamulin is a novel antibiotic with a unique mechanism of action. It represents an alternative option to \u03b2-lactams and macrolides in the treatment of adults with CABP and an alternative option to amoxicillin and doxycycline in the outpatient setting given the rise in resistance to macrolides and safety concerns with fluoroquinolones. Nausea, vomiting, and diarrhea may limit the tolerability of the oral formulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Lefamulin is the first systemic pleuromutilin antibiotic that has proven safe and effective for adults with CABP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1060028020932521","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T04:48:53Z","timestamp":1591246133000},"page":"1203-1214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Lefamulin: The First Systemic Pleuromutilin Antibiotic"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1775-9497","authenticated-orcid":false,"given":"Elias B.","family":"Chahine","sequence":"first","affiliation":[{"name":"Lloyld L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allana J.","family":"Sucher","sequence":"additional","affiliation":[{"name":"Regis University School of Pharmacy, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"bibr1-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027110"},{"key":"bibr2-1060028020932521","unstructured":"US Food and Drug Administration. FDA approves new antibiotic to treat community-acquired bacterial pneumonia. Accessed April 9, 2020. https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-antibiotic-treat-community-acquired-bacterial-pneumonia"},{"key":"bibr3-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix647"},{"key":"bibr4-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks001"},{"key":"bibr5-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02161-18"},{"key":"bibr6-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz087"},{"key":"bibr7-1060028020932521","doi-asserted-by":"publisher","DOI":"10.2174\/138955712798868968"},{"key":"bibr8-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1038\/srep39004"},{"key":"bibr9-1060028020932521","author":"Altabax","year":"2015","journal-title":"GlaxoSmithKline;"},{"key":"bibr10-1060028020932521","author":"Xenleta","year":"2019","journal-title":"Nabriva Therapeutics US Inc;"},{"key":"bibr11-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02158-18"},{"key":"bibr12-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00358-13"},{"key":"bibr13-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05789-11"},{"key":"bibr14-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02106-12"},{"key":"bibr15-1060028020932521","unstructured":"US Food and Drug Administration. Lefamulin oral and injection products. Accessed April 9, 2020. https:\/\/www.fda.gov\/drugs\/development-resources\/lefamulin-oral-and-injection-products"},{"key":"bibr16-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02380-17"},{"key":"bibr17-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00131-06"},{"key":"bibr18-1060028020932521","volume-title":"Paper presented at: 20th European Congress of Clinical Microbiology and Infectious Diseases","author":"Prince WT"},{"key":"bibr19-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02033-13"},{"key":"bibr20-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv442"},{"key":"bibr21-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz086"},{"key":"bibr22-1060028020932521","unstructured":"Center for Drug Evaluation and Research. Multidisciplinary review and evaluation of lefamulin injection and tablets. Accessed May 15, 2020. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2019\/211672Orig1s000,%20211673Orig1s000MultidisciplineR.pdf"},{"key":"bibr23-1060028020932521","volume-title":"Paper presented at: 21st European Congress of Clinical Microbiology and Infectious Diseases","author":"Schmidt U"},{"key":"bibr24-1060028020932521","volume-title":"Paper presented at: IDWeek","author":"Wicha W"},{"key":"bibr25-1060028020932521","volume-title":"Paper presented at: IDWeek","author":"Wicha W"},{"key":"bibr26-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz085"},{"key":"bibr27-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz089"},{"key":"bibr28-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz090"},{"key":"bibr29-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.15468"},{"key":"bibr30-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa145"},{"key":"bibr31-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581"},{"key":"bibr32-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw118."},{"key":"bibr33-1060028020932521","first-page":"136","volume":"72","author":"Peters S.","year":"2019","journal-title":"S D Med"},{"key":"bibr34-1060028020932521","doi-asserted-by":"publisher","DOI":"10.1177\/1715163516641136"},{"key":"bibr35-1060028020932521","volume-title":"Red Book Online","author":"Lefamulin","year":"2020"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028020932521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028020932521","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028020932521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:36Z","timestamp":1777374936000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028020932521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/1060028020932521"],"URL":"https:\/\/doi.org\/10.1177\/1060028020932521","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,4]]}}}