{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:51:27Z","timestamp":1781085087583,"version":"3.54.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review the safety and efficacy of minocycline 4% topical foam for the treatment of moderate to severe acne vulgaris in adults and pediatric patients aged 9 years and older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A literature search through PubMed and EMBASE was conducted using the following keywords: FMX101, minocycline, foam, and acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>Articles selected included those describing preclinical and clinical studies of pharmacokinetics, efficacy, or safety of topical minocycline foam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Minocycline 4% topical foam was shown in a preclinical study to effectively deliver minocycline to the pilosebaceous unit, with little penetration beyond the stratum corneum. This was consistent with a phase 1 pharmacokinetic study of the foam, which yielded a significantly reduced systemic exposure of minocycline compared with oral minocycline. In phase 2 and phase 3 clinical trials, the foam significantly reduced acne lesion counts and Investigator\u2019s Global Assessment scores of acne severity compared with placebo. The foam has a good safety profile, with headache, mild erythema, hyperpigmentation, and mild dryness among the most common adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Patient Care and Clinical Practice:<\/jats:title>\n                    <jats:p>Topical antibiotics have been a mainstay of acne therapy with the benefit of less systemic exposure compared with oral antibiotics. However, the development of bacterial resistance has reduced their use, thereby reducing options for many patients with acne. Minocycline 4% topical foam is a safe and effective alternative, which may help restore this important therapeutic approach for treating acne vulgaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1060028020939926","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T10:06:22Z","timestamp":1593770782000},"page":"105-110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Minocycline Topical Foam: A New Drug for the Treatment of Acne"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-2906","authenticated-orcid":false,"given":"Erin St.","family":"Onge","sequence":"first","affiliation":[{"name":"University of Florida College of Pharmacy, Orlando, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Cary","family":"Mobley","sequence":"additional","affiliation":[{"name":"University of Florida College of Pharmacy, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,3]]},"reference":[{"key":"bibr1-1060028020939926","author":"Amzeeq","year":"2019","journal-title":"Foamix Pharmaceuticals Inc;"},{"key":"bibr2-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"bibr3-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13749"},{"key":"bibr4-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.29"},{"key":"bibr5-1060028020939926","doi-asserted-by":"publisher","DOI":"10.2165\/11319280-000000000-00000"},{"key":"bibr6-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002086.pub2"},{"key":"bibr7-1060028020939926","first-page":"14","volume":"13","author":"Kircik L","year":"2020","journal-title":"J Clin Aesthet Dermatol"},{"key":"bibr8-1060028020939926","unstructured":"Tamarkin D, Eini M, Hazot Y, Shirvan M, Kedem TH, Keynan R. Compositions and methods for treating rosacea and acne. Accessed June 19, 2020. https:\/\/patents.google.com\/patent\/US20180064638A1\/en"},{"key":"bibr9-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2020.102169"},{"key":"bibr10-1060028020939926","doi-asserted-by":"publisher","DOI":"10.15406\/japlr.2017.04.00117"},{"key":"bibr11-1060028020939926","first-page":"1022","volume":"16","author":"Jones TM","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"bibr12-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1080\/1547691X.2019.1610117"},{"key":"bibr13-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.065"},{"key":"bibr14-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.020"},{"key":"bibr15-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0339-0."},{"key":"bibr16-1060028020939926","first-page":"1238","volume":"15","author":"Chamny S","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"bibr17-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.05.078"},{"key":"bibr18-1060028020939926","first-page":"16","volume":"12","author":"Gold LS","year":"2019","journal-title":"J Clin Aesthet Dermatol"},{"key":"bibr19-1060028020939926","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2015.990373"},{"key":"bibr20-1060028020939926","unstructured":"Drugs.com. Amzeeq price, coupons, and patient assistance programs. Accessed June 15, 2020. https:\/\/www.drugs.com\/price-guide\/amzeeq"},{"key":"bibr21-1060028020939926","unstructured":"Amzeeq (minocycline 4% foam). Patient resources. Accessed June 15, 2020. https:\/\/www.amzeeq.com\/acne-patient-resources#savings"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028020939926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028020939926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028020939926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:41Z","timestamp":1777374941000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028020939926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,3]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/1060028020939926"],"URL":"https:\/\/doi.org\/10.1177\/1060028020939926","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,3]]}}}