{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:04:29Z","timestamp":1777421069242,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Discuss the literature and describe strategies to overcome barriers of inpatient initiation of sacubitril\/valsartan in patients with heart failure with reduced ejection fraction (HFrEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A PubMed, EMBASE, and Google Scholar literature search (January 2014 to June 2020) limited to English language articles was conducted with the following terms: sacubitril\/valsartan, initiation, inpatient, hospitalized, B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), diuretic, cost, and cost-effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>Included articles described inpatient initiation of sacubitril\/valsartan or described its impact on BNP, NT-proBNP, diuretic dosing, or cost of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>A total of 20 studies were identified based on included search terms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Sacubitril\/valsartan should be considered for hemodynamically stable patients with HFrEF (New York Heart Association class II or III), potassium &lt;5.2 mmol\/L, without a history of angioedema, and after a 36-hour washout from angiotensin-converting enzyme (ACE) inhibitor or aliskiren, if applicable. An appropriate dose can be determined based on the patient\u2019s previous ACE inhibitor or angiotensin receptor blocker dose and\/or blood pressure along with patient-specific factors. To overcome barriers of use, the following are recommended: NT-proBNP or BNP with establishment of a new baseline 1 month after initiation may be used for prognosis or diagnosis; careful monitoring of diuretic requirements; utilization of multiple strategies to overcome cost barriers; and use of interdisciplinary care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1060028020947446","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T07:14:25Z","timestamp":1596266065000},"page":"480-495","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Inpatient Initiation of Sacubitril\/Valsartan"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-5214","authenticated-orcid":false,"given":"Maya R.","family":"Chilbert","sequence":"first","affiliation":[{"name":"University at Buffalo, NY, USA"},{"name":"Buffalo General Medical Center, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly C.","family":"Rogers","sequence":"additional","affiliation":[{"name":"The University at Tennessee College of Pharmacy, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenique N.","family":"Ciriello","sequence":"additional","affiliation":[{"name":"Buffalo General Medical Center, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-8045","authenticated-orcid":false,"given":"Richard","family":"Rovelli","sequence":"additional","affiliation":[{"name":"UMass Memorial Medical Center, Worcester, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley E.","family":"Woodruff","sequence":"additional","affiliation":[{"name":"University at Buffalo, NY, USA"},{"name":"Buffalo General Medical Center, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"key":"bibr1-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"bibr2-1060028020947446","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2016:25:2"},{"key":"bibr3-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"bibr4-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.09.001"},{"key":"bibr5-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.011"},{"key":"bibr6-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1900139"},{"key":"bibr7-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.1724"},{"key":"bibr8-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.070"},{"key":"bibr9-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915928"},{"key":"bibr10-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812851"},{"key":"bibr11-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.12821"},{"key":"bibr12-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1498"},{"key":"bibr13-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2019.1708638"},{"key":"bibr14-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1177\/0897190019878948"},{"key":"bibr15-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12527"},{"key":"bibr16-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.006"},{"key":"bibr17-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.548"},{"key":"bibr18-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1054"},{"key":"bibr19-1060028020947446","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.580"},{"key":"bibr20-1060028020947446","unstructured":"EntrestoTM (LCZ696) in advanced heart failure (LIFE study) (HFN-LIFE). 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