{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:02:33Z","timestamp":1790136153510,"version":"4.0.1"},"reference-count":114,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["P50GM115305"],"award-info":[{"award-number":["P50GM115305"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health and Medical Research Council of Australia"},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"crossref","award":["R01HG010863"],"award-info":[{"award-number":["R01HG010863"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"crossref","award":["R01AI152183"],"award-info":[{"award-number":["R01AI152183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"crossref","award":["R21AI139021"],"award-info":[{"award-number":["R21AI139021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"crossref","award":["U01AI154659"],"award-info":[{"award-number":["U01AI154659"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review the incidence, management, and current understanding of the pathophysiology of \u03b2-lactam\u2013induced neutropenia and to critically evaluate the practicality and safety of direct substitution to an alternative \u03b2-lactam in the setting of this reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A literature analysis using the PubMed and Ovid search engines (July 1968 to October 2020) was performed using the search terms neutropenia, leukopenia, \u03b2-lactam, nonchemotherapy, agranulocytosis, and G-CSF (granulocyte colony-stimulating factor).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>The included English-language studies evaluated the incidence, mechanism, and\/or management of \u03b2-lactam\u2013induced neutropenia in pediatric or adult patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Drug-induced neutropenia is a well-documented adverse reaction of \u03b2-lactam antibiotics, with an incidence of approximately 10% following at least 2 weeks of intravenous therapy. However, multiple gaps in knowledge remain in the mechanism of pathophysiology and optimal management of this reaction. Both direct toxic and immune-mediated mechanisms have been implicated. Although the cornerstone of management includes cessation of the offending agent, controversy exists on the appropriateness of direct substitution or future use of an alternative \u03b2-lactam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Patient Care and Clinical Practice:<\/jats:title>\n                    <jats:p>Given the frequency of use and superiority of \u03b2-lactams over alternative therapy for several infectious disease states, practical recommendations are needed on the management and safe use of \u03b2-lactams following \u03b2-lactam\u2013induced neutropenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Future use of \u03b2-lactams with differing R1 side chains, particularly those from a separate class, should not be deemed contraindicated following \u03b2-lactam\u2013induced neutropenia and may be considered when indicated, with close laboratory monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1060028020975646","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T08:06:49Z","timestamp":1605859609000},"page":"1037-1049","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["A Review of \u03b2-Lactam\u2013Associated Neutropenia and Implications for Cross-reactivity"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-0026","authenticated-orcid":false,"given":"Christo","family":"Cimino","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ban M.","family":"Allos","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Murdoch University, Murdoch, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"bibr1-1060028020975646","first-page":"569","volume":"2","author":"Kirkwood CF","year":"1983","journal-title":"Clin Pharm"},{"key":"bibr2-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu780"},{"key":"bibr3-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.1.90"},{"key":"bibr4-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.6.607"},{"key":"bibr5-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1086\/379519"},{"key":"bibr6-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12419"},{"key":"bibr7-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L183"},{"key":"bibr8-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv007"},{"key":"bibr9-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx452"},{"key":"bibr10-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1159\/000207758"},{"key":"bibr11-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5611.184"},{"key":"bibr12-1060028020975646","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-69-1-91"},{"key":"bibr13-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb01280.x"},{"key":"bibr14-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1159\/000234000"},{"key":"bibr15-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1128\/aac.1.2.174"},{"key":"bibr16-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39050527.x"},{"key":"bibr17-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb01233.x"},{"key":"bibr18-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb02957.x"},{"key":"bibr19-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6408.1832"},{"key":"bibr20-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320712"},{"key":"bibr21-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.3.323"},{"key":"bibr22-1060028020975646","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-9-200705010-00009"},{"key":"bibr23-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08104.x"},{"key":"bibr24-1060028020975646","first-page":"810","volume":"19","author":"Figueira-Coelho J","year":"2010","journal-title":"J Heart Valve Dis"},{"key":"bibr25-1060028020975646","first-page":"351","volume":"49","author":"Ahern MJ","year":"1976","journal-title":"Yale J Biol Med"},{"key":"bibr26-1060028020975646","first-page":"889","volume":"38","author":"Dutro MP","year":"1981","journal-title":"Am J Hosp Pharm"},{"key":"bibr27-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1001\/jama.240.24.2632c"},{"key":"bibr28-1060028020975646","first-page":"449","volume":"51","author":"Zakhireh B","year":"1978","journal-title":"Yale J Biol Med"},{"key":"bibr29-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1177\/106002808501900205"},{"key":"bibr30-1060028020975646","first-page":"811","volume":"6","author":"Thompson JR","year":"1987","journal-title":"Clin Pharm"},{"key":"bibr31-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(79)91834-8"},{"key":"bibr32-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5618.616-e"},{"key":"bibr33-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03320060074024"},{"key":"bibr34-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(84)91780-x"},{"key":"bibr35-1060028020975646","first-page":"460","volume":"149","author":"Walz B","year":"1988","journal-title":"West J Med"},{"key":"bibr36-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1984.tb05042.x"},{"key":"bibr37-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005456"},{"key":"bibr38-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.36.2.216"},{"key":"bibr39-1060028020975646","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2018.0127"},{"key":"bibr40-1060028020975646","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730040-00002"},{"key":"bibr41-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-3-2"},{"key":"bibr42-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.4.1047-a"},{"key":"bibr43-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1952.x"},{"key":"bibr44-1060028020975646","first-page":"957","volume":"82","author":"McDonald C","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"bibr45-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-232944"},{"key":"bibr46-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G526"},{"key":"bibr47-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1994.tb00635.x"},{"key":"bibr48-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/9.suppl_b.93"},{"key":"bibr49-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/10.6.560"},{"key":"bibr50-1060028020975646","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.697638"},{"key":"bibr51-1060028020975646","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2013.805426"},{"key":"bibr52-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1007\/s150100050042"},{"key":"bibr53-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502900920"},{"key":"bibr54-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/31.suppl_a.113"},{"key":"bibr55-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2301"},{"key":"bibr56-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/60.21.2229"},{"key":"bibr57-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1112"},{"key":"bibr58-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw062"},{"key":"bibr59-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz168"},{"key":"bibr60-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1596"},{"key":"bibr61-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1435"},{"key":"bibr62-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01471-15"},{"key":"bibr63-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32218-9"},{"key":"bibr64-1060028020975646","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-21.4.353"},{"key":"bibr65-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02393.x"},{"key":"bibr66-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/18.supplement_e.193"},{"key":"bibr67-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh209"},{"key":"bibr68-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1542\/peds.61.1.94"},{"key":"bibr69-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(78)90915-7"},{"key":"bibr70-1060028020975646","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2015-0008"},{"key":"bibr71-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.985649"},{"key":"bibr72-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f15fb9"},{"key":"bibr73-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13989"},{"key":"bibr74-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.4.268"},{"key":"bibr75-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810220061007"},{"key":"bibr76-1060028020975646","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-10182019000100112"},{"key":"bibr77-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1978.03630310009008"},{"key":"bibr78-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197811000-00012"},{"key":"bibr79-1060028020975646","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6091"},{"key":"bibr80-1060028020975646","doi-asserted-by":"publisher","DOI":"10.3109\/00365540903380503"},{"key":"bibr81-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(76)80800-1"},{"key":"bibr82-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967266"},{"key":"bibr83-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1376645"},{"key":"bibr84-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy745"},{"key":"bibr85-1060028020975646","doi-asserted-by":"publisher","DOI":"10.12890\/2020_001848"},{"key":"bibr86-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P583"},{"key":"bibr87-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08042.x"},{"key":"bibr88-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1542"},{"key":"bibr89-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ308"},{"key":"bibr90-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.3.449"},{"key":"bibr91-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198212233072611"},{"key":"bibr92-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5857.26"},{"key":"bibr93-1060028020975646","first-page":"121","volume":"74","author":"Lekhakula A","year":"1991","journal-title":"J Med Assoc Thai"},{"key":"bibr94-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1177\/106002808101501015"},{"key":"bibr95-1060028020975646","first-page":"216","volume":"66","author":"Sidi Y","year":"1981","journal-title":"Haematologica"},{"key":"bibr96-1060028020975646","first-page":"666","volume":"72","author":"Chaimongkol B","year":"1989","journal-title":"J Med Assoc Thai"},{"key":"bibr97-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198006000-00019"},{"key":"bibr98-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03250110032018"},{"key":"bibr99-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03250110034019"},{"key":"bibr100-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(78)81251-7"},{"key":"bibr101-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1159\/000457400"},{"key":"bibr102-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu301"},{"key":"bibr103-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197710000-00027"},{"key":"bibr104-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197705000-00018"},{"issue":"135","key":"bibr105-1060028020975646","first-page":"69","author":"Passoff TL","year":"1978","journal-title":"Clin Orthop Relat Res"},{"key":"bibr106-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(77)80413-7"},{"key":"bibr107-1060028020975646","doi-asserted-by":"publisher","DOI":"10.7205\/milmed-d-11-00319"},{"key":"bibr108-1060028020975646","first-page":"10","volume":"5","author":"Mader JT","year":"1982","journal-title":"Clin Ther"},{"key":"bibr109-1060028020975646","first-page":"54","volume":"77","author":"Baumgartner JD","year":"1984","journal-title":"Am J Med"},{"key":"bibr110-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6902.484-a"},{"key":"bibr111-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.suppl_a.161"},{"key":"bibr112-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/54.22.2621"},{"key":"bibr113-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21664"},{"key":"bibr114-1060028020975646","doi-asserted-by":"publisher","DOI":"10.1080\/00365540510040205"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028020975646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028020975646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028020975646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:16:02Z","timestamp":1777374962000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028020975646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":114,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1177\/1060028020975646"],"URL":"https:\/\/doi.org\/10.1177\/1060028020975646","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,20]]}}}