{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:11:49Z","timestamp":1789751509396,"version":"4.0.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with COVID-19 acute respiratory distress syndrome (ARDS) have been shown to have high sedation requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to compare sedative use between patients with COVID-19 ARDS and non-COVID-19 ARDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of patients with COVID-19 ARDS compared with historical controls of non-COVID-19 ARDS who were admitted to 2 hospitals from March 1, 2020, to April 30, 2020, and April 1, 2018, to December 31, 2019, respectively. The primary outcome was median cumulative dose of propofol (\u00b5g\/kg) at 24 hours after intubation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 92 patients with COVID-19 ARDS and 37 patients with non-COVID-19 ARDS included. Within the first 24 hours of intubation, patients with COVID-19 ARDS required higher total median doses of propofol: 51 045 \u00b5g\/kg (interquartile range, 26 150-62 365 \u00b5g\/kg) versus 33 350 \u00b5g\/kg (9632-51 455 \u00b5g\/kg; P = 0.004). COVID-19 patients were more likely receive intravenous lorazepam (37% vs 14%; P = 0.02) and higher cumulative median doses of midazolam by days 5 (14 vs 4 mg; P = 0.04) and 7 of intubation (89 vs 4 mg; P = 0.03) to achieve the same median Richmond Analgesia-Sedation Scale scores. COVID-19 ARDS patients required more ventilator days (10 vs 6 days; P = 0.02). There was no difference in 30-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance<\/jats:title>\n                    <jats:p>Patients with COVID-19 ARDS required higher doses of propofol and benzodiazepines than patients with non-COVID-19 ARDS to achieve the same median levels of sedation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280211021925","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T05:49:16Z","timestamp":1622612956000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Sedation Usage in COVID-19 Acute Respiratory Distress Syndrome: A Multicenter Study"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-1926","authenticated-orcid":false,"given":"Natalie","family":"Tapaskar","sequence":"first","affiliation":[{"name":"Stanford University Medical Center, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Colon Hidalgo","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Koo","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupa","family":"Shingada","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Rao","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alcantar","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Espinoza Barrera","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-2120","authenticated-orcid":false,"given":"Raymond","family":"Lee","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Rameshkumar","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukarram","family":"Amine","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelden","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Giron","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshata","family":"Chaugule","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center MacNeal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A.","family":"Rech","sequence":"additional","affiliation":[{"name":"Loyola University Chicago, Maywood, IL, USA"},{"name":"Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"bibr1-10600280211021925","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25678"},{"key":"bibr2-10600280211021925","doi-asserted-by":"publisher","DOI":"10.5114\/ait.2020.93756"},{"key":"bibr3-10600280211021925","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4914"},{"key":"bibr4-10600280211021925","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06022-5"},{"key":"bibr5-10600280211021925","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0817LE"},{"key":"bibr6-10600280211021925","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004887"},{"key":"bibr7-10600280211021925","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620951426"},{"key":"bibr8-10600280211021925","unstructured":"National Institute of Health. 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