{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:29:07Z","timestamp":1778178547907,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004735","name":"natural science foundation of hunan province","doi-asserted-by":"publisher","award":["2020JJ5869"],"award-info":[{"award-number":["2020JJ5869"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze and discuss the clinical characteristics of dipeptidyl peptidase-4 inhibitor (DPP4i)-induced bullous pemphigoid (BP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>We collected case reports of DPP4i-induced BP by searching databases from 2006 to mid-May 2021, as a retrospective analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction<\/jats:title>\n                    <jats:p>Relevant case reports and case analyses of DPP4i-induced BP were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis<\/jats:title>\n                    <jats:p>The median time of symptom onset was 9 months (range 0.5-59 months). BP most often occurred in patients receiving vildagliptin (52.63%) followed by linagliptin (27.19%) and sitagliptin (17.54%). Tense bullae and blisters (85.51%) and erythema (82.61%) on the extremities and trunk were the most common presenting symptoms. In total, 64.06% of BP patients were anti-BP180 autoantibody positive, 58.97% were BP180NC16a autoantibody positive, and 31.25% were anti-BP230 autoantibody positive. Skin biopsy revealed subepidermal bulla eosinophil infiltration in 93.85% of BP patients, lymphocyte infiltration in 56.93%, and neutrophil infiltration in 44.62%. Direct immunofluorescence was positive in 98.94% of BP patients with linear deposition of IgG (97.80%) and\/or complement C3 (98.94%) along the basement membrane zone. Indirect immunofluorescence was positive in 87.88% of BP patients. Complete remission of BP was achieved in 83.64% of patients on DPP4i withdrawal and after 4 months (range 0.13-72 months) of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Patient Care and Clinical Practice<\/jats:title>\n                    <jats:p>This review analyzes and discusses the clinical characteristics of DPP4i-induced BP and provides a reference for the safe and reasonable clinical application of DPP4i.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DPP4i drugs are related to the occurrence of BP in diabetic patients, especially elderly men taking vildagliptin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280211022722","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T21:22:05Z","timestamp":1623360125000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Analysis of the Clinical Characteristics of Dipeptidyl Peptidase-4 Inhibitor\u2013Induced Bullous Pemphigoid"],"prefix":"10.1177","volume":"56","author":[{"given":"Linli","family":"Sun","sequence":"first","affiliation":[{"name":"Department of general surgery, The Third Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Yinan County People\u2019s Hospital, Linyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuifang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-8305","authenticated-orcid":false,"given":"Chunjiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"bibr1-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1531-1"},{"key":"bibr2-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04345.x"},{"key":"bibr3-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"bibr4-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14368"},{"key":"bibr5-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04919.x"},{"key":"bibr6-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12616580"},{"key":"bibr7-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.03.010"},{"key":"bibr8-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.622"},{"key":"bibr9-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69705-5"},{"key":"bibr10-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.02.010"},{"key":"bibr11-10600280211022722","doi-asserted-by":"publisher","DOI":"10.7326\/M20-2470"},{"key":"bibr12-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111543"},{"key":"bibr13-10600280211022722","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0210"},{"key":"bibr14-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr15-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2020.1787584"},{"key":"bibr16-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14658"},{"key":"bibr17-10600280211022722","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8703-16"},{"key":"bibr18-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14601"},{"key":"bibr19-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12877"},{"key":"bibr20-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12397"},{"key":"bibr21-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3391"},{"key":"bibr22-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.4556"},{"key":"bibr23-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13060"},{"key":"bibr24-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2352"},{"key":"bibr25-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.027"},{"key":"bibr26-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2014.11.002"},{"key":"bibr27-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.04.009"},{"key":"bibr28-10600280211022722","doi-asserted-by":"publisher","DOI":"10.2174\/15665240113136660079"},{"key":"bibr29-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20199007"},{"key":"bibr30-10600280211022722","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1120"},{"key":"bibr31-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8569"},{"key":"bibr32-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12332352"},{"key":"bibr33-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04380.x"},{"key":"bibr34-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02141.x"},{"key":"bibr35-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12732"},{"key":"bibr36-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12967"},{"key":"bibr37-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.11.023"},{"key":"bibr38-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb00739.x"},{"key":"bibr39-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12366"},{"key":"bibr40-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1159\/000106574"},{"key":"bibr41-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12072"},{"key":"bibr42-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15111"},{"key":"bibr43-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13717"},{"key":"bibr44-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.412"},{"key":"bibr45-10600280211022722","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002292.pub3"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280211022722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10600280211022722","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280211022722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:16:16Z","timestamp":1777374976000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10600280211022722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1177\/10600280211022722"],"URL":"https:\/\/doi.org\/10.1177\/10600280211022722","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]}}}