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Even if topical clascoterone, a safe and effective treatment, were more potent than existing topicals, it could face the same poor adherence hurdle as existing treatments. Real-life efficacy will likely not reflect trial results because, for several reasons, adherence is better in trials than in real-life practice. Although topical clascoterone may be exciting initially for its promise to improve acne outcomes, the long-term place in therapy may be another topical option that minimally enhances patients\u2019 treatment outcomes.<\/jats:p>","DOI":"10.1177\/1060028021992055","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T14:16:59Z","timestamp":1612534619000},"page":"1297-1299","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-6477","authenticated-orcid":false,"given":"Caitlin G.","family":"Purvis","sequence":"first","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther A.","family":"Balogh","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA"},{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA"},{"name":"Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA"},{"name":"Department of Dermatology, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"bibr1-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078"},{"key":"bibr2-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.05.008"},{"key":"bibr3-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1177\/1060028021992053"},{"key":"bibr4-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10332.x"},{"key":"bibr5-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.019"},{"key":"bibr6-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/13.1.19"},{"key":"bibr7-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.883"},{"key":"bibr8-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.060"},{"key":"bibr9-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.5254"},{"key":"bibr10-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519847367"},{"key":"bibr11-1060028021992055","first-page":"103","volume":"86","author":"Yentzer BA","year":"2010","journal-title":"Cutis"},{"key":"bibr12-1060028021992055","doi-asserted-by":"publisher","DOI":"10.5070\/D3264048339"},{"key":"bibr13-1060028021992055","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.005"},{"key":"bibr14-1060028021992055","first-page":"32","volume":"5","author":"Decker A","year":"2012","journal-title":"J Clin Aesthet Dermatol"},{"key":"bibr15-1060028021992055","first-page":"31","volume":"8","author":"Del Rosso JQ","year":"2015","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028021992055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028021992055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028021992055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:16:42Z","timestamp":1777375002000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028021992055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/1060028021992055"],"URL":"https:\/\/doi.org\/10.1177\/1060028021992055","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,5]]}}}