{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:24:15Z","timestamp":1793125455767,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Background: Adjunctive vasopressin use in septic shock reduces catecholamine requirements and is associated with a lower incidence of new-onset arrhythmias (NOAs). The association of vasopressin timing on NOA development is ill-described. Objective: To determine whether early administration of vasopressin was associated with a lower incidence of NOA in septic shock patients. Methods: A retrospective analysis of intensive care unit (ICU) patients at a large, academic medical center. Septic shock patients who required vasopressin and norepinephrine were eligible for inclusion. Patients were excluded for receipt of other vasoactive agents, history of cardiac arrhythmias, or outside hospital admission. Early vasopressin was defined as receipt within 6 hours of septic shock onset. The primary outcome was incidence of NOA. Results: In total, 436 patients, 220 (50.4%) in the early and 216 (49.6%) in the late vasopressin group, were included. Early vasopressin was not associated with a lower incidence of NOA compared with late vasopressin (9% vs 7%, median absolute difference [95% confidence interval, CI]: \u22122.1 [\u22127.2, 3.0], P = 0.41). Early vasopressin patients were observed to have shorter shock duration (2 vs 4 days, median absolute difference [95% CI]: 2 [1, 2], P &lt; 0.001), and ICU length of stay (6 vs 7 days, median absolute difference [95% CI]: 1 [0, 2], P = 0.02). Conclusions and Relevance: Early vasopressin use was not associated with a lower incidence of NOA. Additional studies are needed to elucidate the effect of vasopressin timing on NOA and other clinical outcomes.<\/jats:p>","DOI":"10.1177\/10600280221095543","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T01:24:37Z","timestamp":1681435477000},"page":"5-14","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Early Administration of Vasopressin on New-Onset Arrhythmia Development in Patients With Septic Shock: A Retrospective, Observational Cohort Study"],"prefix":"10.1177","volume":"58","author":[{"given":"Michele M.","family":"McCloskey","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle A.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Pope","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bria D.","family":"Giacomino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Hampton","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Micek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, USA"},{"name":"Division of Specialty Care Pharmacy Practice, Saint Louis College of Pharmacy, Saint Louis, MO, USA"},{"name":"Center for Health Outcomes and Education, Saint Louis College of Pharmacy, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marin H.","family":"Kollef","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Washington University School of Medicine, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-359X","authenticated-orcid":false,"given":"Kevin D.","family":"Betthauser","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"bibr1-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003342"},{"key":"bibr2-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"bibr3-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0907118"},{"key":"bibr4-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.02.014"},{"key":"bibr5-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1177\/0885066609340519"},{"key":"bibr6-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003560"},{"key":"bibr7-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1615"},{"key":"bibr8-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201603-0618oc"},{"key":"bibr9-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2730-0"},{"key":"bibr10-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000114579.56430.e0"},{"key":"bibr11-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.2.462"},{"key":"bibr12-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1186\/cc9057"},{"key":"bibr13-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.03.020"},{"key":"bibr14-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-015-0069-5"},{"key":"bibr15-10600280221095543","doi-asserted-by":"publisher","DOI":"10.18865\/ed.26.2.205"},{"key":"bibr16-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.10.023"},{"key":"bibr17-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000251127.45385.CD"},{"key":"bibr18-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000510024.07609.07"},{"key":"bibr19-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1265-y"},{"key":"bibr20-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa067373"},{"key":"bibr21-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10485"},{"key":"bibr22-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000004023"},{"key":"bibr23-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.4528"},{"key":"bibr24-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.03.005"},{"key":"bibr25-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.11.1002.36139"},{"key":"bibr26-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R442"},{"issue":"5","key":"bibr27-10600280221095543","first-page":"671","volume":"42","author":"Bihari D","year":"2014","journal-title":"Anaesth Intensive Care"},{"key":"bibr28-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617725255"},{"key":"bibr29-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2105"},{"key":"bibr30-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198510000-00009"},{"key":"bibr31-10600280221095543"},{"key":"bibr32-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620977181"},{"key":"bibr33-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1177\/10600280211007213"},{"key":"bibr34-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1687-x"},{"key":"bibr35-10600280221095543","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200203000-00011"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280221095543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10600280221095543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280221095543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:16:51Z","timestamp":1777375011000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/10600280221095543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,13]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/10600280221095543"],"URL":"https:\/\/doi.org\/10.1177\/10600280221095543","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,13]]}}}