{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:11:11Z","timestamp":1777421471817,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Haloperidol can be used off-label for agitation and\/or delirium in older individuals. The recommended initial intramuscular or intravenous dose is 0.5 to 1 mg. However, the evidence to support these doses is nominal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary outcome was to determine whether low-dose injectable haloperidol (\u22640.5 mg) was similar in effect to higher doses by assessing the need for repeat doses within 4 hours as a surrogate marker. Secondary outcomes include comparison of length of stay, utilization of restraints, and discharge outcomes between dosage groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective, single-center, cohort study. Patients aged \u226565 years who received haloperidol injectable who were not on antipsychotics prior to admission were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the low-dose group (n = 15), no patients required additional haloperidol doses within 4 hours compared with 1 patient each in the medium-dose (n = 23) and high-dose (n = 19) groups ( P = 0.94). There was a difference regarding length of stay, utilization of restraints, and discharge to facility when admitted from home favoring low-dose haloperidol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance:<\/jats:title>\n                    <jats:p>While limited by sample size and retrospective design, patients who received low-dose haloperidol demonstrated similar efficacy to those who received higher doses of haloperidol. In addition, secondary outcomes mentioned above favored the use of low-dose haloperidol as well. Based on these findings, low-dose haloperidol is a reasonable initial dose for the agitated older patient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280221124615","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T05:28:04Z","timestamp":1663046884000},"page":"662-668","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Optimal Injectable Haloperidol Dose Assessment in the Older Hospitalized Inpatient"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-5047","authenticated-orcid":false,"given":"Jaylan M.","family":"Yuksel","sequence":"first","affiliation":[{"name":"Upstate Community Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay M.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Upstate Community Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Britton","sequence":"additional","affiliation":[{"name":"Upstate University Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harneet","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Upstate University Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Noviasky","sequence":"additional","affiliation":[{"name":"Upstate Community Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"bibr1-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1605501."},{"key":"bibr2-10600280221124615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1176\/ajp.156.1.1","volume":"156","author":"American Psychiatric Association","year":"1999","journal-title":"Am J Psychiatry"},{"key":"bibr3-10600280221124615","unstructured":"Haldol (Haloperidol) [package insert]. Titusville, NJ: Janssen Pharmaceuticals, Inc; 2020."},{"key":"bibr4-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052321."},{"key":"bibr5-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2019.07.023."},{"key":"bibr6-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0087-7."},{"key":"bibr7-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20160177."},{"key":"bibr8-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1159\/000119242."},{"key":"bibr9-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"bibr10-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1697676."},{"key":"bibr11-10600280221124615","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2010.0543."},{"key":"bibr12-10600280221124615","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92909-2."}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280221124615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10600280221124615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280221124615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:17:06Z","timestamp":1777375026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10600280221124615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/10600280221124615"],"URL":"https:\/\/doi.org\/10.1177\/10600280221124615","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}