{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:49Z","timestamp":1787019049431,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether dexmedetomidine (DEX), as adjunctive therapy to benzodiazepine (BZD), is superior to BZD alone in critically ill patients with alcohol withdrawal syndrome (AWS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>PubMed Central, Cochrane CENTRAL, ClinicalTrials.gov and Google Scholar were used as search databases. Specific keywords and MeSH terms were \u201cdexmedetomidine,\u201d \u201cbenzodiazepine,\u201d and \u201calcohol withdrawal syndrome.\u201d The last search was on September 16, 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>Randomized controlled trials (RCTs) and nonrandomized\/cohort studies exploring the use of DEX in the management of AWS were included. A total of 12 studies were included in the systematic review and 7 in the meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>\n                      The intensive care unit length of stay (ICU LOS) was found to have a mean difference (MD) of 48.06 [37.48, 58.64],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = &lt;0.001 for the cohort subgroup, significantly favoring the DEX arm, but, in contrast, pooled RCT data showed a result of \u201320.07 [\u201336.86, \u20133.28],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02, a shorter ICU LOS for the DEX arm. Bradycardia and hypotension incidence significantly favored the BZD arm in both subgroups. This study compares the effectiveness of adjunctive DEX in clinical practice and aims to help providers in critical decision-making by compiling and analyzing the best current available evidence of its use in AWS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Based on low to very low level of evidence, adjunctive DEX showed no significant difference for ICU LOS when compared with BZD alone. Pooled randomized trials potentially show a benefit but are similarly limited by their low quality of evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280221130458","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T01:32:55Z","timestamp":1666143175000},"page":"696-705","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Adjunctive Dexmedetomidine in Alcohol Withdrawal Syndrome: A Systematic Review and Meta-analysis of Retrospective Cohort Studies and Randomized Controlled Trials"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-3472","authenticated-orcid":false,"given":"Edgar Theodore T.","family":"Polintan","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester Mico L.","family":"Danganan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki S.","family":"Cruz","sequence":"additional","affiliation":[{"name":"College of Medicine, Our Lady of Fatima University, Valenzuela, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharina C.","family":"Macapagal","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Alfonso","family":"Catahay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Saint Peter\u2019s University Hospital, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Patarroyo-Aponte","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of Texas Health Science Center at Houston and McGovern Medical School, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zurab","family":"Azmaiparashvili","sequence":"additional","affiliation":[{"name":"Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA"},{"name":"Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Bryan","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA"},{"name":"Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"National Institute on Alcohol Abuse and Alcoholism. 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