{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:56:21Z","timestamp":1793382981261,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The evaluation of bictegravir, emtricitabine, and tenofovir alafenamide (BIC\/FTC\/TAF) in clinical trials has shown high rates of virological suppression but information about its use in real-life settings is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the effectiveness, safety, durability, and predictive variables of therapeutic failure of BIC\/FTC\/TAF in a real-life cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational, retrospective, multicentered cohort study included treatment-naive (TN) and treatment-experienced (TE) adult patients living with HIV (PLWH) who started treatment with BIC\/FTC\/TAF from January 1, 2019, to January 31, 2022. Treatment effectiveness (based on intention-to-treat [ITT], modified ITT [mITT], and on-treatment [OT]), tolerability, and safety were evaluated in all patients who started BIC\/FTC\/TAF antiretroviral therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included a total of 505 PLWH of whom 79 (16.6%) were TN and 426 (83.4%) were TE. Patients were followed up for a median (interquartile range [IQR]) of 19.6 (9.6-27.3) months, and 76% and 56% of PLWH reached month 6 and month 12 of treatment, respectively. Rates of TN PLWH with HIV-RNA &lt;50 copies\/mL in the OT, mITT, and ITT groups were 94%, 80%, and 62%, respectively, after 12 months of BIC\/FTC\/TAF treatment. Rates of TE PLWH with HIV-RNA &lt;50 copies\/mL were 91%, 88%, and 75% at month 12. The multivariate analysis revealed that neither age, sex, CD4 cell count &lt;200 cells\/\u03bcL, or viral load &gt;100 000 copies\/mL were associated with therapeutic failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and relevance:<\/jats:title>\n                    <jats:p>Our real-life data showed that BIC\/FTC\/TAF is effective and safe for use in the treatment of both TN and TE patients in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280231168852","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T01:05:38Z","timestamp":1683075938000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Bictegravir\/Emtricitabine\/Tenofovir Alafenamide in a Multicentre Cohort: Real-Life Experience From Spain"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7405","authenticated-orcid":false,"given":"Miguel","family":"Torralba","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario de Guadalajara, Guadalajara, Spain"},{"name":"Departamento de Medicina y Especialidades M\u00e9dicas, Universidad de Alcal\u00e1, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General Universitario de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Gonz\u00e1lez Gasca","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cuadra","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario de Toledo, Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Barber\u00e1","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General La Mancha-Centro, Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Geijo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General Virgen de la Luz, Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Silva","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Nuestra Se\u00f1ora del Prado, Talavera de la Reina, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General de Almansa, Almansa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Alexander","family":"Ostaiza","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General Universitario de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Garc\u00eda P\u00e9rez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General La Mancha-Centro, Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ram\u00f3n","family":"Larrubia","sequence":"additional","affiliation":[{"name":"Servicio de Gastroenterolog\u00eda, Hospital Universitario de Guadalajara, Guadalajara, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General Universitario de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Lourdes","family":"Porras","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henar","family":"Calvo S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Servicio de Gastroenterolog\u00eda, Hospital Universitario de Guadalajara, Guadalajara, 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