{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:50:06Z","timestamp":1787759406728,"version":"build-2784847793"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Carbapenem-resistant (Car-R) Pseudomonas aeruginosa is an urgent threat. These isolates may remain susceptible to traditional noncarbapenem antipseudomonal \u03b2-lactams, but it is unclear if carbapenem resistance impacts the effectiveness of these agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this study was to compare clinical outcomes in Car-R and cephalosporin-susceptible (Ceph-S) P. aeruginosa pneumonia treated with cefepime versus other susceptible agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study evaluated patients diagnosed with hospital-acquired or ventilator-associated pneumonia who had a respiratory isolate of Car-R Ceph-S P. aeruginosa. Patients were excluded if they had polymicrobial respiratory cultures, other concomitant infections, empyema, death within 3 days of index culture, or received less than 3 days of susceptible therapy. Patients treated with cefepime were compared to other susceptible therapies. The primary endpoint was 30-day in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighty-seven patients were included: cefepime, n = 61; other susceptible therapies, n = 26. There were no differences in 30-day in-hospital mortality between cefepime and other susceptible therapies (19.6% vs. 19.2%, p value = 0.719). In addition, there were no differences between clinical cure rates (cefepime 65.6% vs. other therapies 72 %, p value = 0.47). In multivariate logistic regression, treatment with cefepime (odds ratio [OR], 0.57; 95% confidence interval [CI], 0.11-2.52) was not independently associated with 30-day in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>For the treatment of Car-R Ceph-S P. aeruginosa pneumonia, cefepime showed similar rates of 30-day in-hospital mortality and clinical outcomes when compared to other susceptible therapies. Cefepime may be utilized to conserve novel \u03b2-lactam and \u03b2-lactamase inhibitors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280231201953","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T02:19:56Z","timestamp":1695781196000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment Outcomes for Carbapenem-Resistant and Cephalosporin-Susceptible\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Pneumonia"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4405-8783","authenticated-orcid":false,"given":"Tsz Hin","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, DMC Detroit Receiving Hospital, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing J.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, DMC Harper University Hospital, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Gumbleton","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, DMC Harper University Hospital, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, DMC Sinai-Grace Hospital, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Baylor University Medical Center, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco R.","family":"Scipione","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, DMC Detroit Receiving Hospital, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"bibr1-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1086\/653053"},{"key":"bibr2-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1586\/eri.09.108"},{"key":"bibr3-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.013"},{"key":"bibr4-10600280231201953","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9040153"},{"key":"bibr5-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1556\/030.66.2019.036"},{"key":"bibr6-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2016.10.008"},{"key":"bibr7-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.11.014"},{"key":"bibr8-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00582-2017"},{"key":"bibr9-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"bibr10-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad428"},{"key":"bibr11-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.05.017"},{"key":"bibr12-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ411"},{"key":"bibr13-10600280231201953","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.09.008"},{"key":"bibr14-10600280231201953","volume-title":"M100: 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