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The purpose of this commentary is to discuss the unanswered questions regarding buprenorphine in the intensive care unit (ICU) including how the passage of the MAT Act will affect ICU providers, which patients should receive buprenorphine, what is the most appropriate route of administration and dose of buprenorphine, what medications interact with buprenorphine, and how can transitions of care be optimized for these patients.<\/jats:p>","DOI":"10.1177\/10600280241254528","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T01:29:46Z","timestamp":1715909386000},"page":"184-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Buprenorphine in the Intensive Care Unit: Commentary on the Unanswered Questions"],"prefix":"10.1177","volume":"59","author":[{"given":"David J.","family":"Gagnon","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Maine Medical Center, Portland, ME, USA"},{"name":"MaineHealth Institute for Research, Scarborough, ME, USA"},{"name":"Tufts University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melody J.","family":"Glenn","sequence":"additional","affiliation":[{"name":"Banner\u2013University Medical Center Tucson Base Hospital, Tucson, AZ, USA"},{"name":"Emergency Medicine & Psychiatry, University of Arizona College of Medicine\u2013Tucson, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-2164","authenticated-orcid":false,"given":"Aurora A.","family":"Quaye","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine, Boston, MA, USA"},{"name":"Department of Anesthesiology & Perioperative Medicine, Maine Medical Center, Portland, ME, USA"},{"name":"Spectrum Healthcare Partners, South Portland, ME, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-9921","authenticated-orcid":false,"given":"Brian L.","family":"Erstad","sequence":"additional","affiliation":[{"name":"University of Arizona College of Pharmacy, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"bibr1-10600280241254528","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2021-103007"},{"key":"bibr2-10600280241254528","unstructured":"Substance Abuse and Mental Health Services Administration. 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