{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:24:26Z","timestamp":1785608666886,"version":"3.56.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["22K15331"],"award-info":[{"award-number":["22K15331"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Piperacillin\/tazobactam (PIPC\/TAZ), which is a combination of a beta-lactam\/beta-lactamase inhibitor, often causes liver enzyme abnormalities. The albumin-bilirubin (ALBI) score is a simple index that uses the serum albumin and total bilirubin levels for estimating hepatic functional reserve. Although patients with low hepatic reserve may be at high risk for drug-induced liver enzyme abnormalities, the relationship between PIPC\/TAZ-induced abnormal liver enzymes levels and the ALBI score remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to elucidate the relationship between PIPC\/TAZ-induced abnormal liver enzyme levels and the ALBI score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-center retrospective case-control study included 335 patients. The primary outcome was PIPC\/TAZ-induced abnormal liver enzyme levels. We performed COX regression analysis with male gender, age (\u226575 years), alanine aminotransferase level (\u226520 IU\/L), and ALBI score (\u2265\u22122.00) as explanatory factors. To investigate the influence of the ALBI score on the development of abnormal liver enzyme levels, 1:1 propensity score matching between the \u2264\u22122.00 and \u2265\u22122.00 ALBI score groups was performed using the risk factors for drug-induced abnormal liver enzyme levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The incidence of abnormal liver enzyme levels was 14.0% (47\/335). COX regression analysis revealed that an ALBI score \u2265\u22122.00 was an independent risk factor for PIPC\/TAZ-induced abnormal liver enzyme levels (adjusted hazard ratio: 3.08, 95% coefficient interval: 1.207-7.835, P = 0.019). After 1:1 propensity score matching, the Kaplan-Meier curve revealed that the cumulative risk for PIPC\/TAZ-induced abnormal liver enzyme levels was significantly higher in the ALBI score \u2265\u22122.00 group (n = 76) than in the &lt;\u22122.00 group (n = 76) ( P = 0.033).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and relevance:<\/jats:title>\n                    <jats:p>An ALBI score \u2265\u22122.00 may predict the development of PIPC\/TAZ-induced abnormal liver enzyme levels. Therefore, frequent monitoring of liver enzymes should be conducted to minimize the risk of severe PIPC\/TAZ-induced abnormal liver enzyme levels in patients with low hepatic functional reserve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280241255837","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T02:15:15Z","timestamp":1717640115000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Decreased Hepatic Functional Reserve Increases the Risk of Piperacillin\/Tazobactam-Induced Abnormal Liver Enzyme Levels: A Retrospective Case-Control Study"],"prefix":"10.1177","volume":"59","author":[{"given":"Hayahide","family":"Ooi","sequence":"first","affiliation":[{"name":"Department of Pharmacy, National Hospital Organization Mie Chuo Medical Center, Tsu, 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