{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:38:45Z","timestamp":1793093925785,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This article reviews the published data encompassing the development, pharmacology, efficacy, and safety of travoprost, intracameral implant, a treatment for reduction of intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A literature search was conducted from drug discovery until September 2024 through PubMed, MEDLINE, and National Institutes of Health Clinical Trials Registry utilizing the following search terms: iDose, travoprost, intracameral implant, OTX-TIC, open-angle glaucoma, and ocular hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>All relevant English-language studies, or studies that could be appropriately translated into English, containing the pharmacology, pharmacokinetics, safety, and efficacy of travoprost intracameral implant were selected for review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Travoprost implants showed significant reductions in IOP compared with other treatment options with fewer limitations often associated with topical medications resulting in travoprost implant patients favoring reduced concomitant use of topical IOP-lowering medications (with 81% of patients being medication free).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Patient Care and Clinical Practice in Comparison with Existing Drugs:<\/jats:title>\n                    <jats:p>Due to limited compliance with topical treatment modalities, the travoprost implant presents a promising alternative pathway for drug delivery. With a duration of 3 years and removal of the need for patient dexterity and application compliance, the travoprost implant serves an unmet need for patients and prescribers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Travoprost intracameral implant is a safe and effective delivery system for intracameral travoprost administration for patients with OAG or ocular hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280241291911","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:37:39Z","timestamp":1733877459000},"page":"767-772","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Travoprost Intracameral Implant: A Review on the Novel Treatment Modality for Open-Angle Glaucoma and Ocular Hypertension"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-2108","authenticated-orcid":false,"given":"Jessica","family":"Huston","sequence":"first","affiliation":[{"name":"Department of Pharmacy Education and Practice, College of Pharmacy, University of Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-5156","authenticated-orcid":false,"given":"Mark","family":"Paauw","sequence":"additional","affiliation":[{"name":"Florida Eye Specialists, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dontia","family":"Orey","sequence":"additional","affiliation":[{"name":"East Coast Institute for Research, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Centner","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Central Florida, Orlando, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Hasan","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Central Florida, Orlando, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Shetty","sequence":"additional","affiliation":[{"name":"Florida Eye Specialists, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Freidl","sequence":"additional","affiliation":[{"name":"Florida Eye Specialists, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Goldfaden","sequence":"additional","affiliation":[{"name":"East Coast Institute for Research, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.04.051"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.10.022"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001943"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01973-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2024.02.022"},{"key":"e_1_3_2_9_2","unstructured":"ClinicalTrialsgov. Clinical study comparing two models of a travoprost intraocular implant. Date Unknown. Accessed August 28 2024. https:\/\/clinicaltrials.gov\/study\/NCT03868124?tab=results"},{"key":"e_1_3_2_10_2","unstructured":"Glaukos. Glaukos announces FDA approval of iDose\u00aeTR (travoprost intracameral implant). Published December 14 2023. Accessed August 28 2024. https:\/\/investors.glaukos.com\/investors\/news\/news-details\/2023\/Glaukos-Announces-FDA-Approval-of-iDoseTR-travoprost-intracameral-implant\/default.aspx"},{"key":"e_1_3_2_11_2","volume-title":"i Dose TR (Travoprost Intracameral Implant), for Intracameral Administration Package Insert","author":"Glaukos Corp","year":"2023","unstructured":"Glaukos Corp. i Dose TR (Travoprost Intracameral Implant), for Intracameral Administration Package Insert. Glaukos Corp; 2023."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-024-00898-y"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.17925\/usor.2023.17.1.4"},{"key":"e_1_3_2_14_2","unstructured":"Glaukos. Glaukos receives permanent J-code for iDose\u00ae TR (travoprost intracameral implant). Published April 3 2024. Accessed August 28 2024. https:\/\/investors.glaukos.com\/investors\/news\/news-details\/2024\/Glaukos-Receives-Permanent-J-code-for-iDose-TR-travoprost-intracameral-implant\/default.aspx"},{"key":"e_1_3_2_15_2","unstructured":"Drugs.com. Durysta prices coupons copay cards & patient assistance (no date). Accessed August 28 2024. https:\/\/www.drugs.com\/price-guide\/durysta"},{"key":"e_1_3_2_16_2","unstructured":"Drugs.com. Travoprost ophthalmic prices coupons copay cards & patient assistance (no date). Accessed August 28 2024. https:\/\/www.drugs.com\/price-guide\/travoprost-ophthalmic"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-019-00222-z"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280241291911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10600280241291911","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280241291911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:13:54Z","timestamp":1777374834000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10600280241291911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/10600280241291911"],"URL":"https:\/\/doi.org\/10.1177\/10600280241291911","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]}}}