{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:53:20Z","timestamp":1777420400777,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Finnish Governmental Research Funding"},{"name":"Betania Foundation"},{"name":"State Research Funding of the Turku University Hospital expert responsibility area"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cholinesterase inhibitors (ChEIs)\u2014donepezil, rivastigmine, and galantamine\u2014are beneficial in treating Alzheimer disease (AD). However, due to their impact on extra-cerebral acetylcholine signaling, concerns about cardiac adverse effects, including QT interval prolongation, persist. Despite this, evidence-based guidelines for electrocardiogram (ECG) monitoring during ChEI treatment are lacking, and prior studies on ChEIs and corrected QT intervals (QTc) yield inconsistent findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the association between ChEI use and changes in QTc intervals among older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We collected retrospective data from first-time visitors to the geriatric memory clinic of Turku City Hospital in 2017 and 2019. We included patients who were newly prescribed ChEIs and had ECG data available (n = 126, mean age 81.1 years, 56.3% female). QTc prolongation was defined as \u2265460 ms in females and \u2265450 ms in men. Paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      tests compared QTc means before and during ChEI use, and McNemar tests analyzed changes in the proportion of prolonged QTc.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean \u00b1 SD QTc (ms) before versus during ChEI use was: 420.8 \u00b1 24.0 versus 423.9 \u00b1 28.0 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .13) for donepezil; 416.0 \u00b1 20.4 versus 416.5 \u00b1 26.1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .92) for galantamine; 416.1 \u00b1 22.3 versus 409.6 \u00b1 20.1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .30) for rivastigmine; and 419.7 \u00b1 23.4 versus 421.5 \u00b1 27.3 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .34) for all ChEIs. Prolonged QTc occurred in 7.9% of patients before versus 12.7% during ChEI use (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .21).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>We found no statistically significant association between ChEI use and QTc interval prolongation or an increased proportion of pathological QTc values during ChEI treatment. Larger studies are warranted to establish evidence-based recommendations on ECG monitoring during ChEI medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280251328530","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T03:26:06Z","timestamp":1746501966000},"page":"42-52","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Cholinesterase Inhibitor Medication on QTc Interval in Memory Clinic Patients"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8923-4152","authenticated-orcid":false,"given":"Hanna Karita","family":"Isotalo","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Faculty of Medicine, Turku University Hospital, University of Turku, Turku, Finland"},{"name":"Southwest Finland Wellbeing Services County, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1656-4106","authenticated-orcid":false,"given":"Joanna Karoliina","family":"Lehtovaara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-8088","authenticated-orcid":false,"given":"Laura Linnea","family":"Ekblad","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Faculty of Medicine, Turku University Hospital, University of Turku, Turku, Finland"},{"name":"Southwest Finland Wellbeing Services County, Turku, Finland"},{"name":"Turku PET Centre, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-6084","authenticated-orcid":false,"given":"Maria Susanna","family":"Nuotio","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Faculty of Medicine, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-7962","authenticated-orcid":false,"given":"Ville Lauri Johannes","family":"Lang\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Faculty of Medicine, Turku University Hospital, University of Turku, Turku, Finland"},{"name":"Division of Medicine, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organisation. 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