{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:53:43Z","timestamp":1777420423751,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      (PA) bacteremia is associated with poor clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this study was to evaluate treatment effect and patient outcomes from different antimicrobials for PA bacteremia from 2020 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This was a retrospective review of 2020 to 2022 hospitalized patients with PA bacteremia at our institution. Patients from January 2020 to July 2022 with culture-positive PA were identified. Data collected included demographics, hospitalization and drug treatment length, vasopressor use or mechanical ventilation, and admission acute and physiologic health evaluation II score (APACHE II) score and hospital mortality. Directed therapy for PA, including dose, interval, and minimal inhibitory concentration (MIC) data, was evaluated. Data were analyzed by SPSS. Data are presented as mean \u00b1 SD or percentage. A priori significance was\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 111 PA bacteremias occurred from 2020 to 2022; 65% of patients were male. Mean (\u00b1 SD) age was 71 \u00b1 13 years, and weight was 89.7 \u00b1 23 kg. Mean hospitalization length and duration of antibiotics were 12 \u00b1 13 days and 7.1 \u00b1 5.9 days, respectively. The PA bacteremia was treated with piperacillin-tazobactam (45%) or cefepime (43%). Thirty- seven (33%) PA-infected patients expired. Significantly more 8 of 18 (44%) cefepime patients died when receiving 4 g\/d (1 g q 6 h) compared with 1 (9%) of 11 receiving 6 g\/d (2 g q 8 h) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The APACHE II score was significantly higher for expired patients (survival 13.9 \u00b1 5.7; expired 22 \u00b1 8.3 group,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance:<\/jats:title>\n                    <jats:p>The APACHE II score was significantly higher for PA bacteremic patients who expired. Treatment of the bacteremia with cefepime 4 g\/d resulted in significant mortality compared to 6 g\/d.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280251339770","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:34:27Z","timestamp":1748219667000},"page":"53-58","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating Cefepime Dosing Strategies in\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Bacteremia: A Retrospective Cohort Analysis"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-3939","authenticated-orcid":false,"given":"Chris","family":"Destache","sequence":"first","affiliation":[{"name":"Schools of Medicine and Pharmacy &amp; Health Professions, Creighton University, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Witherspoon","sequence":"additional","affiliation":[{"name":"Schools of Medicine and Pharmacy &amp; Health Professions, Creighton University, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey","family":"Yeates","sequence":"additional","affiliation":[{"name":"Schools of Medicine and Pharmacy &amp; Health Professions, Creighton University, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Quimby","sequence":"additional","affiliation":[{"name":"Schools of Medicine and Pharmacy &amp; Health Professions, Creighton University, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faran","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Schools of Medicine and Pharmacy &amp; Health Professions, Creighton University, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renuga","family":"Vivekanandan","sequence":"additional","affiliation":[{"name":"Schools of Medicine and Pharmacy &amp; Health Professions, Creighton University, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/375081"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.09.018"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/591698"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-009-9145-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01102.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz223"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/514912"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/338782"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/504477"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06365-11"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/528712"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00580-08"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg403"},{"key":"e_1_3_2_15_2","volume-title":"Performance Standards for Antimicrobial Susceptiblity Testing","author":"Institute CLSI","year":"2019","unstructured":"Institute CLSI. 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