{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:15:29Z","timestamp":1784614529001,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006108","name":"national center for advancing translational sciences","doi-asserted-by":"publisher","award":["UL1TR001998"],"award-info":[{"award-number":["UL1TR001998"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cockcroft-Gault (eCrCl) remains the industry standard for estimating renal function in hospitalized patients despite known limitations. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C (eGFRcr-cys) equation was developed to ameliorate these limitations and is now preferred in specific outpatient scenarios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to determine patient-specific factors associated with a &gt;25 milliliters per minute (mL\/min) difference where eCrCl exceeds eGFRcr-cys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective, Institutional Review Board approved, observational review included data from June 2021 to December 2022. Adults with serum cystatin C and creatinine collected within 24-hours of admission were included. Exclusions included pregnancy or renal replacement therapy. The primary endpoint was to identify patient-specific predictors of a &gt;25 mL\/min discrepancy between eCrCl and eGFRcr-cys. The secondary outcome was to determine odds ratios for identified patient-specific characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 235 encounters, 67 had a &gt;25 mL\/min difference where eCrCl exceeded eGFRcr-cys. Multivariate regression identified the following independent predictors of this difference: age &lt;58 years (odds ratio [OR] 2.722; 95% confidence interval [CI] 1.357-5.459), weight &gt;105 kg (OR: 9.079; 95% CI: 4.344-18.978), intensive care unit (ICU) admission within 24 hours (OR 2.779; 95% CI 1.248-6.188) and diagnosis of paraplegia or quadriplegia (OR 5.490; 95% CI 1.523-19.796).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>This study concluded that eCrCl may exceed eGFRcr-cys by &gt;25 mL\/min in patients presenting for hospital admission with one or more predictors: age &lt;58 years, weight &gt;105 kg, intensive care unit (ICU) admission, or diagnosis of paraplegia or quadriplegia. Current literature suggests improved accuracy of renal clearance estimations with eGFRcr-cys. Accordingly, practitioners should consider eGFRcr-cys when evaluating new admissions with these characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280251356492","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T02:33:53Z","timestamp":1756348433000},"page":"338-346","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of Discrepancies Between Cockcroft-Gault and Chronic Kidney Disease-EPI Creatinine-Cystatin in Hospitalized Patients"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2976-9474","authenticated-orcid":false,"given":"Savannah S.","family":"Poole","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audis","family":"Bethea","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9532-2795","authenticated-orcid":false,"given":"Eden","family":"Brewington","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Cornett","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan L.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-7282","authenticated-orcid":false,"given":"Ann Marie","family":"Stoll","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aric","family":"Schadler","sequence":"additional","affiliation":[{"name":"Kentucky Children\u2019s Hospital, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Leonhard","sequence":"additional","affiliation":[{"name":"Dr. Bing Zhang Department of Statistics, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Cincinnati Health, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4519-2749","authenticated-orcid":false,"given":"Alexandra","family":"Sutphin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/mjt.0000000000000568"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.09.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7812\/tpp\/11-121"},{"key":"e_1_3_2_6_2","volume-title":"Frequently Asked Questions About GFR Estimates","author":"Stevens L","year":"2004","unstructured":"Stevens L, Levey A. 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