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Switching to liquid or softgel formulations can enhance levothyroxine bioavailability and symptom control. Optimizing therapy requires individualized approaches, including dietary intervention, formulation changes, and close monitoring, to achieve and maintain a euthyroid state. Relevant studies were reviewed and incorporated into this commentary to support evidence-based recommendations and highlight clinical considerations.<\/jats:p>","DOI":"10.1177\/10600280251361914","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:39:23Z","timestamp":1753785563000},"page":"303-305","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Levothyroxine Absorption in Patients With Celiac Disease: Challenges and Therapeutic Strategies"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-4837","authenticated-orcid":false,"given":"Maha","family":"Saad","sequence":"first","affiliation":[{"name":"College of Pharmacy and Health Sciences, St. John\u2019s University, Queens, NY, USA"},{"name":"Drug Information Services, Long Island Jewish Medical Center, New Hyde Park, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2772-301X","authenticated-orcid":false,"given":"Nicole M.","family":"Maisch","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Health Sciences, St. John\u2019s University, Queens, NY, USA"},{"name":"Drug Information Services, Long Island Jewish Medical Center, New Hyde Park, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i35.3932"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.26243"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/127589"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120689"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.09.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2013.09.01.40"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12094"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0476-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0706-y"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.09.003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00168"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ten.0000153022.67326.61"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4170"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25491"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2022.0078"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-016-0150-z"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.432"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S414460"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2023.09.003"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280251361914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10600280251361914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280251361914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:14:15Z","timestamp":1777374855000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10600280251361914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/10600280251361914"],"URL":"https:\/\/doi.org\/10.1177\/10600280251361914","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]}}}