{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:56:49Z","timestamp":1777420609686,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Guidelines recommend arginine vasopressin (AVP) at a fixed dose for patients with septic shock who remain hypotensive after fluid resuscitation and norepinephrine, regardless of body weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study seeks to evaluate whether body weight affects hemodynamic response (HDR) to AVP in critically ill patients with septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a single-center, retrospective cohort study of adult patients with septic shock. Patients received AVP at a fixed rate of 0.03 units\/min in addition to catecholamine vasopressors and were grouped into 4 categories according to admission body weight. The primary endpoint was the time from AVP initiation to HDR, defined as a decrease in norepinephrine equivalents (NEEs) by at least 0.03 mcg\/kg\/min while maintaining a mean arterial pressure of at least 65 mm Hg for 1 hour. Secondary endpoints included a time to HDR defined as reduction in NEE of 0.05 mcg\/kg\/min, intensive care unit (ICU) length of stay (LOS), total duration of vasoactive agents, incidence of renal replacement therapy (RRT), and 28-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 170 patients were included in the study. No differences were observed between categories in time to HDR of 0.03 NEE (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.854) or 0.05 NEE (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.985). The total duration of vasopressors and ICU LOS were also similar between categories (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). Patients weighing &lt;75 kg had a lower incidence of RRT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and patients weighing &lt;100 kg had a lower 28-day mortality (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006). These findings remained significant after regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>Although body weight did not have a significant impact on the time to HDR, there was a significant difference in the incidence of RRT and 28-day mortality favoring those who weighed &lt;75 and &lt;100 kg, respectively. These findings contribute to the existing body of evidence, though larger trials are warranted to assess this further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280261436423","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:37:06Z","timestamp":1776692226000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Body Weight on Hemodynamic Response to Vasopressin in Patients With Septic Shock"],"prefix":"10.1177","author":[{"given":"Eli O.","family":"Jorgensen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, University of Florida Health Shands Hospital, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1490-0398","authenticated-orcid":false,"given":"Marco M.","family":"Custodio","sequence":"additional","affiliation":[{"name":"Department of 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