{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:53:05Z","timestamp":1791039185152,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>P2Y12 inhibitor acquisition and continuation after ischemic stroke or transient ischemic attack (TIA) are incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe postdischarge clopidogrel and ticagrelor uptake, persistence, switching, bleeding diagnoses, and trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective descriptive cohort study used US claims (2020-2025). Adults with a first qualifying inpatient ischemic stroke or inpatient\/emergency-department TIA from July 2020 through December 2024 were included. Fills were assessed through 90\u2009days. Persistence and 1-year bleeding diagnoses were evaluated among continuously enrolled initiators; switching was assessed through follow-up of 365\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 45\u2009763 patients, 8667 (18.9%) filled a P2Y12 inhibitor within 30\u2009days: 8226 clopidogrel (94.9% of initiators) and 441 ticagrelor (5.1%). Among 5641 continuously enrolled initiators, clopidogrel versus ticagrelor persistence was 66.3% versus 78.3% at day 90 and 50.5% versus 59.6% at day 180; it was low for both at day 365. Switching occurred in 2.9%; 23.8% of ticagrelor initiators later filled clopidogrel versus 1.7% in the reverse direction. Crude 1-year intracerebral hemorrhage and gastrointestinal bleeding diagnosis rates were 2.6% and 5.8%. Overall uptake rose from 18.3% in July to December 2020 to 20.9% in 2024. Claims did not reliably capture over-the-counter aspirin, clinical eligibility, ingestion, or reasons for changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>Fewer than 1 in 5 adults with coded ischemic stroke or TIA filled a P2Y12 inhibitor within 30\u2009days. These data benchmark outpatient acquisition and persistence, not guideline adherence or comparative effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280261487728","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:00:52Z","timestamp":1790852452000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-World Postdischarge P2Y12 Inhibitor Use After Ischemic Stroke and Transient Ischemic Attack, 2020 to 2024"],"prefix":"10.1177","author":[{"given":"Adnan I.","family":"Qureshi","sequence":"first","affiliation":[{"name":"Zeenat Qureshi Stroke Institutes, Columbia, MO, USA"},{"name":"Department of Neurology, University of Missouri School of Medicine, Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7691-4917","authenticated-orcid":false,"given":"Hassan","family":"Raza","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institutes, Columbia, MO, USA"},{"name":"Department of Neurology, University of Missouri School of Medicine, Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Tolba","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Missouri School of Medicine, Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjanpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Missouri School of Medicine, Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Missouri School of Medicine, Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sandifer","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Specialist, University of Missouri Health Care, Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Shing","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mid Cheshire Hospitals NHS Foundation Trust, Leighton Hospital, Crewe, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo R.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Missouri School of Medicine, Columbia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fareed K.","family":"Suri","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institutes, Columbia, MO, USA"},{"name":"Department of Neurology, CentraCare-St. Cloud Hospital, St. Cloud, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215340"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800410"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603060"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916870"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4396"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2211"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111749"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309137"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.31938"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/singaporemedj.SMJ-2024-064"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.11735"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822f0423"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.4408"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031164"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.048"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.24157"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.0323"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2026.108564"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280261487728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10600280261487728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10600280261487728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:05:15Z","timestamp":1791036315000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10600280261487728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":19,"alternative-id":["10.1177\/10600280261487728"],"URL":"https:\/\/doi.org\/10.1177\/10600280261487728","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"10600280261487728"}}