{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:46:33Z","timestamp":1792154793042,"version":"4.4.0"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001772","name":"University of New England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for mood disorders. Their association with musculoskeletal side effects raises the question of potential SSRI impact on exercise-induced muscle damage and recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this prospective cohort study was to determine if SSRI use influences muscle function following a bout of eccentric exercise designed to induce delayed onset muscle soreness (DOMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Subjects between 18 and 30\u2009years of age were recruited in a university setting. This included 1 group taking SSRIs prescribed by their health care provider, and a control group not using SSRIs. Subjects performed a DOMS induction protocol consisting of 300 eccentric knee extensions on an isokinetic dynamometer. Muscle soreness, thigh circumference, quadriceps flexibility, and isometric quadriceps strength were measured at baseline and at 24-, 48-, 72-, and 96-hour post-DOMS protocol. Comparisons were made between SSRI users and control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty-six subjects included 18 SSRI users and 18 controls. The DOMS protocol induced muscle soreness in both groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001 when compared with baseline). At 72\u2009hours a between-group difference was observed for thigh muscle flexibility (MD\u2009=\u200911.2, SE\u2009=\u20095.0, 95% CI [0.9, 21.4],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.033, \u03b7p\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.126) but no additional significant between-group differences in soreness, strength, thigh circumference, or flexibility were noted at any timepoint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>In this population, SSRI use had no effect on muscle soreness, circumference, or strength of the quadriceps following eccentric DOMS-inducing exercise. A difference in flexibility between SSRI and control groups at a single time point likely reflects a Type 1 error and is not likely of clinical consequence. These findings suggest SSRIs do not impair short-term recovery from exercise-induced muscle damage in healthy young adults, but potential SSRI impacts on longer-term training adaptations and recovery in athletic populations remain unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10600280261493982","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:03:21Z","timestamp":1791986601000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Potential Impact of Selective Serotonin Reuptake Inhibitors on Delayed Onset Muscle Soreness: A Prospective Cohort Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1033-2741","authenticated-orcid":false,"given":"Jack","family":"Deitch","sequence":"first","affiliation":[{"name":"Department of Exercise and Sport Performance, University of New England, Biddeford, ME, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-1028","authenticated-orcid":false,"given":"Michele","family":"LaBotz","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Performance, University of New England, Biddeford, ME, USA"},{"name":"Department of Pediatrics, Tufts University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Lamarre","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Performance, University of New England, Biddeford, ME, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Michael","sequence":"additional","affiliation":[{"name":"Department of Human Performance and Health Education, Western Michigan University, Kalamazoo, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Visich","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Performance, University of New England, Biddeford, ME, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0038550"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint13030038"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.84944"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2513"},{"issue":"12","key":"e_1_3_5_6_2","article-title":"Escitalopram-associated rhabdomyolysis","volume":"143","author":"Mathisen KK","year":"2023","unstructured":"Mathisen KK, Hardersen R. 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