{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:42:03Z","timestamp":1777416123850,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1983,2,1]],"date-time":"1983-02-01T00:00:00Z","timestamp":412905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:p>Amiodarone, although widely studied in Europe, is a recent addition to the investigational antiarrhythmics being used in the U.S. Pharmacologically, its primary cardiac effects are to increase coronary artery blood flow, increase the effective refractory period, and produce an atropine-resistant bradycardia.<\/jats:p>\n                  <jats:p>Amiodarone is incompletely (~ 50 percent) and slowly (peak serum concentration ~ 6 h) absorbed. With chronic administration, it deposits both in adipose tissue and in organs with high blood perfusion. It has an apparent elimination half-life of 15\u201345 days, which presents unique dosing problems. The apparent therapeutic range is 0.6-3 \u03bcg\/ml.<\/jats:p>\n                  <jats:p>Amiodarone is 85\u201395 percent effective in the treatment of atrial tachyarrhythmias and 70\u201380 percent effective in ventricular tachyarrhythmias. It appears to be of particular value in chronic atrial fibrillation\/flutter because it may be able to maintain sinus rhythm after cardioversion.<\/jats:p>\n                  <jats:p>Side effects, although uncommon, may prevent the drug from becoming a standard of therapy. Drug interactions, particularly with warfarin and digoxin, as well as pulmonary fibrosis are of concern.<\/jats:p>","DOI":"10.1177\/106002808301700203","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T04:59:56Z","timestamp":1512449996000},"page":"100-104","source":"Crossref","is-referenced-by-count":25,"title":["Amiodarone for Tachyarrhythmias: Pharmacology, Kinetics, and Efficacy"],"prefix":"10.1177","volume":"17","author":[{"given":"Andrew T.","family":"Canada","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Clinical Pharmacy, and Pharmacology and Medicine, University of Massachusetts Medical Center, Worcester, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J.","family":"Lesko","sequence":"additional","affiliation":[{"name":"Clinical Pharmacokinetics Laboratory, and Pharmacy, School of Pharmacy, University of Maryland, Baltimore, MD;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles I.","family":"Haffajee","sequence":"additional","affiliation":[{"name":"Cardiology, and Coronary Care Units and Electrophysiology and Pacing Clinics;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Johnson","sequence":"additional","affiliation":[{"name":"Medicine and Pharmacology;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George K.","family":"Asdourian","sequence":"additional","affiliation":[{"name":"Opthalmology, University of Massachusetts Medical Center, Worcester, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"bibr1-106002808301700203","first-page":"247","volume":"139","author":"Deltour G.","year":"1962","journal-title":"Arch Intern Pharmacodyn"},{"key":"bibr2-106002808301700203","first-page":"483","volume":"22","author":"Vastesaeger M.","year":"1967","journal-title":"Acta Cardiol"},{"key":"bibr3-106002808301700203","first-page":"105","volume":"49","author":"Barzin J.","year":"1969","journal-title":"Brux Med"},{"key":"bibr4-106002808301700203","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000166244","volume":"54","author":"Charlier R.","year":"1969","journal-title":"Cardiology"},{"key":"bibr5-106002808301700203","first-page":"1849","volume":"78","author":"Van Schepdael J.","year":"1970","journal-title":"Nouv Presse Med"},{"key":"bibr6-106002808301700203","first-page":"323","volume":"22","author":"Charlier R.","year":"1967","journal-title":"Acta Cardiol"},{"key":"bibr7-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1970.tb09891.x"},{"key":"bibr8-106002808301700203","first-page":"1408","volume":"18","author":"Charlier R.","year":"1968","journal-title":"Arzneim Forsch"},{"key":"bibr9-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(76)90109-6"},{"key":"bibr10-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.6.1165"},{"key":"bibr11-106002808301700203","first-page":"340","volume":"1772","author":"Broekhuysen J.","year":"1969","journal-title":"Arch Intern Pharmacodyn"},{"key":"bibr12-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600701219"},{"key":"bibr13-106002808301700203","first-page":"968","volume":"30","author":"Canada A.","year":"1981","journal-title":"Curr Ther Res"},{"key":"bibr14-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1007\/BF00562807"},{"key":"bibr15-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(74)90200-8"},{"key":"bibr16-106002808301700203","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/106002808001400916","volume":"14","author":"Canada A.","year":"1980","journal-title":"Drug Intell Clin Pharm"},{"key":"bibr17-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90148-X"},{"key":"bibr18-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90807-9"},{"key":"bibr19-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(81)90124-1"},{"key":"bibr20-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(81)90140-X"},{"key":"bibr21-106002808301700203","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6278.1756-a"},{"key":"bibr22-106002808301700203","first-page":"45","volume-title":"Amiodarone in cardiac arrhythmias. 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