{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:40:12Z","timestamp":1777416012414,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1983,10,1]],"date-time":"1983-10-01T00:00:00Z","timestamp":433814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>Plasma levels and blood pressure responses to two dosage regimens of phenylpropanolamine (PPA)\u201425-mg, immediate-release tablets three times per day and a 75-mg, controlled-release capsule once per day\u2014were compared in 14 normal subjects. To obtain steady-state conditions, subjects were given the test materials for four-day periods, and blood pressure and plasma PPA levels were measured on day 4. The dosage forms were equally bioavailable, based on a 95-percent confidence coefficient, and neither produced hypertensive effects. The highest diastolic pressure was 96 mm Hg three hours after a 25-mg dose. Mean PPA plasma levels showed no correlation with mean blood pressure readings at any point during a 12-hour test period. These data show that, in these subjects, a daily dosage of PPA 75 mg, either in divided doses of 25 mg each or in a dependable controlled-release formula, produces no indication of pressor effects.<\/jats:p>","DOI":"10.1177\/106002808301701012","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T03:53:02Z","timestamp":1508903582000},"page":"746-750","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Effects of Two Dosage Regimens of Phenylpropanolamine on Blood Pressure and Plasma Levels in Normal Subjects under Steady-State Conditions"],"prefix":"10.1177","volume":"17","author":[{"given":"Marcus B.","family":"Saltzman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Doyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,25]]},"reference":[{"key":"bibr1-106002808301701012","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1979.tb128964.x"},{"key":"bibr2-106002808301701012","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90490-0"},{"key":"bibr3-106002808301701012","unstructured":"Weight control drug products for over-the-counter human use: establishment of a monograph. Federal Register Feb 26, 1982."},{"key":"bibr4-106002808301701012","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/jps.2600650530","volume":"65","author":"Neelakantan L","year":"1976","journal-title":"J Pharm Sci"},{"key":"bibr5-106002808301701012","doi-asserted-by":"publisher","DOI":"10.2307\/2529259"},{"key":"bibr6-106002808301701012","doi-asserted-by":"publisher","DOI":"10.1177\/030006057900700312"},{"key":"bibr7-106002808301701012","first-page":"47","volume":"10","author":"Mitchell CA","year":"1968","journal-title":"Ther Res"},{"key":"bibr8-106002808301701012","first-page":"260","volume":"25","author":"Unger DL","year":"1967","journal-title":"Ann Allergy"},{"key":"bibr9-106002808301701012","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320320028025"}],"container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808301701012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808301701012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:01:15Z","timestamp":1777374075000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/106002808301701012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1177\/106002808301701012"],"URL":"https:\/\/doi.org\/10.1177\/106002808301701012","relation":{},"ISSN":["0012-6578"],"issn-type":[{"value":"0012-6578","type":"print"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}