{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:46:59Z","timestamp":1777416419198,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1984,3,1]],"date-time":"1984-03-01T00:00:00Z","timestamp":446947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:p>In a double-blind study, a timed-release tablet containing carbinoxamine maleate 8 mg and pseudoephedrine hydrochloride 120 mg was compared with placebo for the treatment of signs and symptoms of nasal allergy. Ninety-four adults with rhinitis caused by grass or ragweed allergy were paired according to severity of symptoms and nasal congestion, then assigned randomly to drug or placebo. After baseline measurements were taken, three doses of drug or placebo were given at 12-hour intervals. The active drug was significantly better than placebo in relieving the following symptoms: nasal congestion, nose blowing, sneezing, nasal pruritus, rhinorrhea, ophthalmic pruritus, and sniffles. Improvement over baseline in mean total nasal air flow also was greater in subjects given active drug. The incidence of nonspecific symptoms, including possible drug side effects, was similar between groups. We conclude that the timed-release tablet is safe and effective therapy for the treatment of signs and symptoms of nasal allergy.<\/jats:p>","DOI":"10.1177\/106002808401800314","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T12:10:02Z","timestamp":1462968602000},"page":"244-247","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of a Timed-Release Antihistamine\/Decongestant Tablet for Symptoms of Nasal Allergy"],"prefix":"10.1177","volume":"18","author":[{"given":"John T.","family":"Connell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Zola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Paule","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,3,1]]},"reference":[{"key":"bibr1-106002808401800314","unstructured":"American Medical Association Department of Drugs. AMA drug evaluations. 4th ed. Chicago: American Medical Association, 1980: 459."},{"key":"bibr2-106002808401800314","first-page":"75","volume":"45","author":"Falliers CJ","year":"1980","journal-title":"Ann Allergy"},{"key":"bibr3-106002808401800314","first-page":"179","volume":"49","author":"Connell JT","year":"1982","journal-title":"Ann Allergy"},{"key":"bibr4-106002808401800314","first-page":"278","volume":"42","author":"Connell JT","year":"1979","journal-title":"Ann Allergy"},{"key":"bibr5-106002808401800314","first-page":"87","volume":"48","author":"Hamilton LH","year":"1982","journal-title":"Ann Allergy"},{"key":"bibr6-106002808401800314","first-page":"87","volume":"47","author":"Diamond L","year":"1981","journal-title":"Ann Allergy"},{"key":"bibr7-106002808401800314","first-page":"43","volume":"22","author":"Hamilton LH","year":"1979","journal-title":"Physiologist"},{"key":"bibr8-106002808401800314","first-page":"610","volume-title":"Goodman and Gilman's the pharmacological basis of therapeutics","author":"Douglas WW","year":"1980","edition":"6"}],"container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808401800314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808401800314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:02:10Z","timestamp":1777374130000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002808401800314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["10.1177\/106002808401800314"],"URL":"https:\/\/doi.org\/10.1177\/106002808401800314","relation":{},"ISSN":["0012-6578"],"issn-type":[{"value":"0012-6578","type":"print"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}