{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:47:30Z","timestamp":1777416450963,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1984,4,1]],"date-time":"1984-04-01T00:00:00Z","timestamp":449625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p>Tobacco smoking may interact with the metabolism of a number of drugs. This has been demonstrated clearly in pharmacokinetic studies in animals and man. However, tobacco smoking as a variant has been studied with relatively few clinically essential drugs and these studies do not always demonstrate a consistent effect of smoking.<\/jats:p>\n                  <jats:p>This review therefore not only records what data have emerged from pharmacokinetic or other studies, but it also attempts to determine whether such interactions have clinical significance.<\/jats:p>\n                  <jats:p>The main finding of this review is that, in the majority of examples, there is little evidence that there is a recognizable hazard from the interaction per se. The exceptions to this general conclusion are limited to four drugs: insulin, propoxyphene, propranolol, and theophylline preparations. With these drugs, there is some evidence of clinical importance of an interaction with tobacco smoking.<\/jats:p>","DOI":"10.1177\/106002808401800405","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T11:15:39Z","timestamp":1462965339000},"page":"302-307","source":"Crossref","is-referenced-by-count":13,"title":["Tobacco Smoking and Drugs: A Clinically Important Interaction?"],"prefix":"10.1177","volume":"18","author":[{"given":"P.F.","family":"D'Arcy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,4,1]]},"reference":[{"key":"bibr1-106002808401800405","first-page":"1143","volume":"58","author":"Jick H","year":"1974","journal-title":"Med Clin NA"},{"key":"bibr2-106002808401800405","first-page":"1647","volume":"36","author":"Conney AH","year":"1977","journal-title":"Fed 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