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A concomitant decline in platelet count and increase in heparin requirements should alert the clinician to the possible presence of this disorder.<\/jats:p>\n                  <jats:p>A 36-year-old black male developed severe thrombocytopenia with thrombosis while being treated with porcine intestinal mucosal heparin. Platelet counts returned to near-normal levels upon discontinuation of heparin, but quickly dropped again upon resuming treatment with bovine lung heparin. The patient subsequently was treated with warfarin and dipyridamole, with no further complications.<\/jats:p>\n                  <jats:p>Treatment of delayed-onset severe heparin-induced thrombocytopenia consists of stopping the heparin and substituting antiplatelet agents and oral anticoagulants when continued inhibition of coagulation is required.<\/jats:p>","DOI":"10.1177\/106002808401800508","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T11:14:11Z","timestamp":1462965251000},"page":"398-401","source":"Crossref","is-referenced-by-count":2,"title":["Heparin-Induced Thrombocytopenia-Association with a Platelet Aggregating Factor and Cross-Sensitivity to Bovine and Porcine Heparin"],"prefix":"10.1177","volume":"18","author":[{"given":"David 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