{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:45:16Z","timestamp":1777416316273,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1984,12,1]],"date-time":"1984-12-01T00:00:00Z","timestamp":470707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1984,12]]},"abstract":"<jats:p>Three adult subjects, each with a ventriculostomy, received ceftazidime 2g iv q8h for three doses. Serial samples of serum and CSF ventricular fluid were obtained following the third dose; ceftazidime concentrations were measured by high pressure liquid chromatography. In one patient without inflammatory cells in the CSF, ceftazidime CSF concentrations were only \u223c0.3 \u03bcg\/ml. In two other patients who had inflammatory cells and blood in the CSF, concentrations of ceftazidime in ventricular fluid demonstrated a slow rise and decline over an eight-hour period. Although contamination of the CSF by blood in these two patients confounds the interpretation of the concentrations achieved, it is concluded that obtaining serial samples of CSF from a ventriculostomy offers a more realistic appraisal of the dynamics of antibiotic penetration compared with the single-point method.<\/jats:p>","DOI":"10.1177\/106002808401801209","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T11:14:50Z","timestamp":1462965290000},"page":"984-987","source":"Crossref","is-referenced-by-count":3,"title":["Sequential Ventricular Fluid Concentrations of Ceftazidime\u2014Report of Three Cases"],"prefix":"10.1177","volume":"18","author":[{"given":"Ronald E.","family":"Polk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Glen","family":"Mayhall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Tartaglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Baggett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,12,1]]},"reference":[{"key":"bibr1-106002808401801209","doi-asserted-by":"publisher","DOI":"10.1177\/106002808101500505"},{"key":"bibr2-106002808401801209","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/AAC.19.3.407","volume":"19","author":"Verbist L","year":"1981","journal-title":"Antimicrob Agents Chemother"},{"key":"bibr3-106002808401801209","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90240-0"},{"key":"bibr4-106002808401801209","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/jac\/11.2.198","volume":"11","author":"Modai J","year":"1982","journal-title":"J Antimicrob Chemother"},{"key":"bibr5-106002808401801209","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/jac\/8.suppl_B.227","volume":"8","author":"Ayrton J","year":"1981","journal-title":"J Antimicrob Chemother"},{"key":"bibr6-106002808401801209","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600650713"},{"key":"bibr7-106002808401801209","first-page":"630","volume":"9","author":"Norrby R","year":"1982","journal-title":"J Antimicrob Chemother"},{"key":"bibr8-106002808401801209","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/infdis\/143.2.156","volume":"143","author":"Schaael U","year":"1981","journal-title":"J Infect Dis"},{"key":"bibr9-106002808401801209","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1128\/AAC.24.1.126","volume":"24","author":"Modai J","year":"1983","journal-title":"Antimicrob Agents Chemother"},{"key":"bibr10-106002808401801209","unstructured":"Fong I, Tomkins K. Ceftazidime cerebrospinal fluid penetration in inflamed and non-inflamed meninges. Twenty-third Interscience Conference on Antimicrobial Agents and Chemotherapy. Oct. 24\u201326, 1983, Las Vegas, Nevada (Abstract no. 828)."},{"key":"bibr11-106002808401801209","unstructured":"Blumer J, Reed M, Aronoff S, Myers C. CSF penetration and pharmacokinetics (PK) of ceftazidime (CAZ) in children with bacterial meningitis (M). Twenty-third Interscience Conference on Antimicrobial Agents and Chemotherapy. Oct. 24\u201326, 1983, Las Vegas, Nevada (Abstract no. 830)."},{"key":"bibr12-106002808401801209","unstructured":"Hawkins S, Bechard D, Finn A. CSF penetration of ceftazidime in patients with meningitis. Twenty-third Interscience Conference on Antimicrobial Agents and Chemotherapy. Oct. 24\u201326, 1983, Las Vegas, Nevada (Abstract no. 831)."},{"key":"bibr13-106002808401801209","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/jac\/12.suppl_A.275","volume":"12","author":"Walstad RA","year":"1983","journal-title":"J Antimicrob Chemother"},{"key":"bibr14-106002808401801209","first-page":"671","volume-title":"Histology and histopathology of the nervous system","author":"Adams RD","year":"1982"}],"container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808401801209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808401801209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:01:56Z","timestamp":1777374116000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002808401801209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1984,12]]}},"alternative-id":["10.1177\/106002808401801209"],"URL":"https:\/\/doi.org\/10.1177\/106002808401801209","relation":{},"ISSN":["0012-6578"],"issn-type":[{"value":"0012-6578","type":"print"}],"subject":[],"published":{"date-parts":[[1984,12]]}}}