{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:16Z","timestamp":1777417096134,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1985,2,1]],"date-time":"1985-02-01T00:00:00Z","timestamp":476064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1985,2]]},"abstract":"<jats:p>A 37-year-old female developed erythema multiforme 17 days after beginning carbamazepine for complex partial seizures. The carbamazepine was discontinued and Phenytoin begun. A new rash developed and Phenytoin therapy was stopped. In vitro immunologic studies were conducted in an effort to understand the pathogenesis of the rashes. Enhancement of stimulated in vitro lymphocyte proliferation from the patient occurred in the presence of carbamazepine and Phenytoin. Neither drug had an enhancing effect on lymphocyte proliferation from a control subject. These data, together with clinical data, strongly suggest an immunologic pathogenesis for drug-induced erythema multiforme.<\/jats:p>","DOI":"10.1177\/106002808501900206","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T05:08:40Z","timestamp":1512450520000},"page":"114-117","source":"Crossref","is-referenced-by-count":9,"title":["Drug-Induced Erythema Multiforme: A Possible Immunologic Pathogenesis"],"prefix":"10.1177","volume":"19","author":[{"given":"Jeffrey C.","family":"Delafuente","sequence":"first","affiliation":[{"name":"Pharmacy and Medicine, Department of Pharmacy Practice, College of Pharmacy, and Department of Medicine, Division of Clinical Immunology, College of Medicine, University of Florida, Gainesville, FL."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"bibr1-106002808501900206","first-page":"179","volume":"19","author":"PANUSH R.S.","year":"1979","journal-title":"Int J Vitam Nutr Res"},{"key":"bibr2-106002808501900206","first-page":"331","volume":"44","author":"DELAFUENTE JC","year":"1980","journal-title":"Ann Allergy"},{"key":"bibr3-106002808501900206","volume-title":"Ficoll-Paque.","author":"Package insert.","year":"1979"},{"key":"bibr4-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(79)70030-2"},{"key":"bibr5-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80003-6"},{"key":"bibr6-106002808501900206","first-page":"15","volume":"3","author":"MEISEL S.","year":"1984","journal-title":"Clin Pharm"},{"key":"bibr7-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12543935"},{"key":"bibr8-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb05687.x"},{"key":"bibr9-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12543806"},{"key":"bibr10-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12543789"},{"key":"bibr11-106002808501900206","first-page":"366","volume-title":"Basic and clinical immunology.","author":"SITES D.P.","year":"1982"},{"key":"bibr12-106002808501900206","first-page":"997","volume":"86","author":"REIDENBERG M.M.","year":"1975","journal-title":"J Lab Clin Med"},{"key":"bibr13-106002808501900206","first-page":"272","volume":"29","author":"HOUWERZIJL J.","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"bibr14-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430078041"},{"key":"bibr15-106002808501900206","first-page":"273","volume":"20","author":"SORRELL T.C.","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"bibr16-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(80)90065-2"},{"key":"bibr17-106002808501900206","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1977.tb16795.x"},{"key":"bibr18-106002808501900206","first-page":"283","volume":"5","author":"GILHUS N.E.","year":"1983","journal-title":"Int J Pharmacol"},{"key":"bibr19-106002808501900206","first-page":"213","volume":"17","author":"ROBERTS D.L.","year":"1981","journal-title":"Arch Dermatol"}],"container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808501900206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808501900206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:03:14Z","timestamp":1777374194000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/106002808501900206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,2]]}},"alternative-id":["10.1177\/106002808501900206"],"URL":"https:\/\/doi.org\/10.1177\/106002808501900206","relation":{},"ISSN":["0012-6578"],"issn-type":[{"value":"0012-6578","type":"print"}],"subject":[],"published":{"date-parts":[[1985,2]]}}}