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The potential for withdawal reactions is probably greater for the shorter-acting agents than the longer-acting drugs. Potentially dependent sedative\/hypnotic users require stabilization of their symptoms initially, followed by tolerance testing. If tolerant, the patients should be withdrawn using either a long-acting sedative\/hypnotic (e.g., diazepam) or phenobarbital. Compared to other benzodiazepines and barbiturates, diazepam appears to be the drug of choice for treating dependent patients. Diazepam is rapidly adsorbed and distributed to the brain and therefore useful for stabilization and tolerance testing. It is metabolized on chronic administration to a long-acting metabolite, desmethyldiazepam, which makes the drug ideal for a tapered withdrawal schedule.<\/jats:p>","DOI":"10.1177\/106002808602000702","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T03:53:27Z","timestamp":1508903607000},"page":"532-537","source":"Crossref","is-referenced-by-count":33,"title":["Sedative\/Hypnotic Dependence: Patient Stabilization, Tolerance Testing, and Withdrawal"],"prefix":"10.1177","volume":"20","author":[{"given":"Paul J.","family":"Perry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,10,25]]},"reference":[{"key":"bibr1-106002808602000702","volume-title":"National Institute on Drug Abuse. 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