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Second- and third-generation cephalosporins, ureidopenicillins, acylamino penicillins, and monobactams generally are resistant to hydrolysis by these enzymes. However, inducible \u03b2-lactamases may confer resistance to these antibiotics. This induction may occur spontaneously or in response to cefoxitin or other \u03b2-lactam agents. The mechanisms by which inducible enzymes produce this resistance are reviewed and implications for the prophylactic and therapeutic use of newer \u03b2-lactams are considered.<\/jats:p>","DOI":"10.1177\/106002808602000711","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T03:53:27Z","timestamp":1508903607000},"page":"562-567","source":"Crossref","is-referenced-by-count":2,"title":["Emergence of Resistance in Gram-Negative Bacteria: A Risk of Broad-Spectrum Beta-Lactam Use"],"prefix":"10.1177","volume":"20","author":[{"given":"David 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