{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:04:08Z","timestamp":1777417448094,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1986,10,1]],"date-time":"1986-10-01T00:00:00Z","timestamp":528508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:p>A case of vancomycin-induced neutropenia is presented with a review of other reported cases in the literature. A 59-year-old white female was started on vancomycin therapy for a chronic infection of a total left hip replacement.<\/jats:p>\n                  <jats:p>\n                    After 38 days of treatment, the patient developed a severe leukopenia with a white blood cell count of 1700\/mm\n                    <jats:sup>3<\/jats:sup>\n                    and the presence of only occasional neutrophils. Upon discontinuation of vancomycin, the leukocyte and neutrophil counts promptly increased with full recovery in one week. Subsequently, the patient was restarted on a five-day course of vancomycin at a lower dose that proved uneventful with no recurrence of neutropenia. It is unclear whether the neutropenia would have recurred with a longer course of vancomycin.\n                  <\/jats:p>\n                  <jats:p>A review of the literature suggests that an immunologic mechanism may be responsible for the reaction. Physicians and other health professionals should be aware that neutropenia is a potential reaction of patients receiving prolonged vancomycin treatment.<\/jats:p>","DOI":"10.1177\/106002808602001010","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T03:55:34Z","timestamp":1508903734000},"page":"780-782","source":"Crossref","is-referenced-by-count":16,"title":["Vancomycin-Induced Neutropenia"],"prefix":"10.1177","volume":"20","author":[{"given":"Kenneth B.","family":"Koo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Bachand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony W.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,25]]},"reference":[{"key":"bibr1-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.1.138"},{"key":"bibr2-106002808602001010","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-55-2-235"},{"key":"bibr3-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03300220012007"},{"key":"bibr4-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92598-8"},{"key":"bibr5-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198110000-00028"},{"key":"bibr6-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198209000-00029"},{"key":"bibr7-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.4.575"},{"key":"bibr8-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198405000-00034"},{"key":"bibr9-106002808602001010","first-page":"39","volume":"132","author":"Mackett RL","year":"1985","journal-title":"Can Med Assoc J"},{"key":"bibr10-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90915-7"},{"key":"bibr11-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03270150038029"},{"key":"bibr12-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90766-0"},{"key":"bibr13-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1979.03630420070022"},{"key":"bibr14-106002808602001010","first-page":"1061","volume":"90","author":"McCarthy DD","year":"1964","journal-title":"Can Med Assoc J"},{"key":"bibr15-106002808602001010","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198212000-00032"}],"container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808602001010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808602001010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:49Z","timestamp":1777374289000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/106002808602001010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1986,10]]}},"alternative-id":["10.1177\/106002808602001010"],"URL":"https:\/\/doi.org\/10.1177\/106002808602001010","relation":{},"ISSN":["0012-6578"],"issn-type":[{"value":"0012-6578","type":"print"}],"subject":[],"published":{"date-parts":[[1986,10]]}}}