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A change in the serum phenytoin concentration of \u00b1 4 \u03bcg\/ml was considered clinically significant; by this definition four patients (14.8 percent) had an increase, two (7.4 percent) had a decrease, and most (77.8 percent) demonstrated no change. The mean difference was 0.8 \u03bcg\/ml \u00b1 3.7 \u03bcg\/ml and was not found to be statistically significant (p &lt; 0.1). Clinically important alterations in phenytoin serum concentration as caused by thioridazine appear to be infrequent.<\/jats:p>","DOI":"10.1177\/106002808702100307","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T06:57:40Z","timestamp":1463554660000},"page":"267-272","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Thioridazine on Phenytoin Serum Concentration: A Retrospective Study"],"prefix":"10.1177","volume":"21","author":[{"given":"Charles D.","family":"Sands","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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