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Statistically significant differences in inflammatory lesions, erythema, and global assessments were seen at three, six, and nine weeks post-baseline in favor of the active treatment side. It did not, however, alter the telangiectatic component of the disease. No known drug-related side effects were detected, and the low topical dose along with low serum levels of metronidazole indicate a high safety profile for this therapeutic agent. This work suggests that metronidazole gel, as specifically formulated, is safe and effective in reducing the symptomatology of acne rosacea.<\/jats:p>","DOI":"10.1177\/106002808702100410","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T11:52:47Z","timestamp":1486986767000},"page":"346-351","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of Topical Metronidazole Gel in Acne Rosacea"],"prefix":"10.1177","volume":"21","author":[{"given":"Iris K.","family":"Aronson","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean A.","family":"Rumsfield","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, and Department of Pharmacy Practice, College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis P.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, and Department of Pharmacy Practice, College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, and Clinical Pharmacokinetics Laboratory, College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P.","family":"Paloucek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, and Clinical Pharmacokinetics Laboratory, College of Pharmacy, University of Illinois at Chicago."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"bibr1-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1966.tb12168.x"},{"key":"bibr2-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90376-X"},{"key":"bibr3-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92160-7"},{"key":"bibr4-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb06558.x"},{"key":"bibr5-106002808702100410","first-page":"197","volume":"164","author":"Braun VW","year":"1918","journal-title":"Dermatol Monatsschr"},{"key":"bibr6-106002808702100410","first-page":"1960","volume":"7","author":"Guilhou J-J","year":"1978","journal-title":"Press Med"},{"key":"bibr7-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb03972.x"},{"key":"bibr8-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb03993.x"},{"key":"bibr9-106002808702100410","first-page":"141","volume":"58","author":"Doring HF","year":"1983","journal-title":"Z Hautkr"},{"key":"bibr10-106002808702100410","first-page":"209","volume":"38","author":"Veien NK","year":"1986","journal-title":"Cutis"},{"key":"bibr11-106002808702100410","volume-title":"Nonparametric statistics for the behavioral sciences.","author":"Siegal S","year":"1956"},{"key":"bibr12-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1983.201"},{"key":"bibr13-106002808702100410","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.5.721"},{"key":"bibr14-106002808702100410","unstructured":"GibaldiM, PerrierD. 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