{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:54:06Z","timestamp":1777416846742,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1987,5,1]],"date-time":"1987-05-01T00:00:00Z","timestamp":546825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:p>Falsely elevated serum digoxin values have recently been reported in patients with liver disease. Since not all patients have circulatory digoxin-like immunoreactive substance (DLIS) in their serum, we compared the clinical and laboratory findings in patients with and without DLIS. Thirty-two patients with liver disease were studied. The only parameter that was significantly different in the two groups was serum bilirubin. In the group of patients with DLIS, significant correlations were obtained between DLIS and bilirubin and DLIS and creatinine. We postulate that increased levels of DLIS in serum are due to an abnormality of DLIS excretion.<\/jats:p>","DOI":"10.1177\/106002808702100515","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T05:46:48Z","timestamp":1487051208000},"page":"450-452","source":"Crossref","is-referenced-by-count":5,"title":["Digoxin-Like Immunoreactive Substance (DLIS) in Liver Disease: Comparison of Clinical and Laboratory Parameters in Patients with and without DLIS"],"prefix":"10.1177","volume":"21","author":[{"given":"Alan","family":"Gervais","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Kingston General Hospital, Kingston, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin A.","family":"Nanji","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy and Laboratory Medicine, Ottawa General Hospital, and University of Ottawa, Ottawa, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald C.","family":"Greenway","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy and Laboratory Medicine, Ottawa General Hospital, and University of Ottawa, Ottawa, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Mclean","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy and Laboratory Medicine, Ottawa General Hospital, and University of Ottawa, Ottawa, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,5,1]]},"reference":[{"key":"bibr1-106002808702100515","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-5-604"},{"key":"bibr2-106002808702100515","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-4-567_2"},{"key":"bibr3-106002808702100515","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-4-748"},{"key":"bibr4-106002808702100515","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304143081516"},{"key":"bibr5-106002808702100515","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6466.432"},{"key":"bibr6-106002808702100515","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198506000-00011"},{"key":"bibr7-106002808702100515","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/31.6.1078a"},{"key":"bibr8-106002808702100515","first-page":"2800","volume":"44","author":"Valdes R","year":"1985","journal-title":"Fed Proc"}],"container-title":["Drug Intelligence &amp; Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808702100515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002808702100515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:02:51Z","timestamp":1777374171000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002808702100515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["10.1177\/106002808702100515"],"URL":"https:\/\/doi.org\/10.1177\/106002808702100515","relation":{},"ISSN":["0012-6578"],"issn-type":[{"value":"0012-6578","type":"print"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}