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It is useful as a diuretic in conditions such as cirrhosis and congestive heart failure, and is most commonly employed because of its potassium- and magnesium-sparing qualities. Spironolactone also has been used as an antiandrogenic agent in managing hirsutism. Its adverse effect profile, considered somewhat prohibitive in the past, is generally not significant when reasonably low doses (&lt;150 mg\/d) are used.<\/jats:p>","DOI":"10.1177\/106002809002400112","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T04:42:42Z","timestamp":1501735362000},"page":"52-59","source":"Crossref","is-referenced-by-count":7,"title":["Spironolactone: A Re-Examination"],"prefix":"10.1177","volume":"24","author":[{"given":"Hilary A.","family":"Skluth","sequence":"first","affiliation":[{"name":"College of Pharmacy, Southeastern University of the Health Sciences, Miami, FL;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Gums","sequence":"additional","affiliation":[{"name":"Colleges of Pharmacy and Medicine, University of Florida, Gainesville, 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