{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:57:00Z","timestamp":1790873820477,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DICP"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:p>\n                    The use of positron emission tomography (PET) has been well documented as a relatively noninvasive method of measuring cerebral blood flow (CBF), both globally and regionally. The utility of readily detecting alterations in CBF is apparent, particularly when applied to the evaluation of therapeutic interventions thought to influence CBF. We report the effects of hypocapnia, an experimental condition of known cerebral vasoconstriction, in ten normal volunteers. Subjects had brain blood flow evaluated utilizing H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O as the positron emitter before and after approximately five minutes of hyperventilation. Baseline CBF was measured as a mean \u00b1 SD of 61.2 \u00b1 16.3 mL\/min\/100 g of tissue. Mean baseline arterial blood gas values were PaO\n                    <jats:sub>2<\/jats:sub>\n                    107.4 \u00b1 14 mm Hg, PaCO\n                    <jats:sub>2<\/jats:sub>\n                    37.7 \u00b1 0.89 mm Hg, and pH 7.39 (calculated from mean [H\n                    <jats:sup>+<\/jats:sup>\n                    ]). Post hyperventilation, global CBF was measured as 31.1 \u00b1 10.8 mL\/min\/100 g. Mean arterial blood gas values were PaO\n                    <jats:sub>2<\/jats:sub>\n                    141.7 \u00b1 21 mm Hg, PaCO\n                    <jats:sub>2<\/jats:sub>\n                    19.7 \u00b1 5 mm Hg, and pH 7.63 (calculated from mean [H\n                    <jats:sup>+<\/jats:sup>\n                    ]). CBF decreased by a mean of 49.5 \u00b1 11 percent. Data analysis using the Student's t-est showed a significant change over baseline in PaCO\n                    <jats:sub>2<\/jats:sub>\n                    (p&lt;0.001) and CBF (p&lt;0.001), in the hyperventilated state. Correlations were noted between the decrease in CBF and change in PaCO\n                    <jats:sub>2<\/jats:sub>\n                    (r = 0.81) as well as between hyperventilation PaCO\n                    <jats:sub>2<\/jats:sub>\n                    and the change in CBF (r=0.97). We conclude that, as measured by PET, CBF decreases significantly during a state of artificial hyperventilation to a degree consistent with results seen using other methods. PET appears to be a valuable tool in the assessment of interventions that could influence CBF.\n                  <\/jats:p>","DOI":"10.1177\/106002809002400501","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:45:02Z","timestamp":1498783502000},"page":"456-460","source":"Crossref","is-referenced-by-count":16,"title":["Hyperventilation-Induced Reduction in Cerebral Blood Flow: Assessment by Positron Emission Tomography"],"prefix":"10.1177","volume":"24","author":[{"given":"Edward M.","family":"Bednarczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Rutherford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Leisure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Munger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Panacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floro D.","family":"Miraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1990,5,1]]},"reference":[{"key":"bibr-bibr1-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1126\/science.2860723"},{"key":"bibr-bibr2-106002809002400501","first-page":"616","volume":"26","author":"Huang SC","year":"1985","journal-title":"J Nucl Med"},{"key":"bibr-bibr3-106002809002400501","first-page":"790","volume":"24","author":"Raichle ME","year":"1983","journal-title":"J Nucl Med"},{"key":"bibr-bibr4-106002809002400501","first-page":"S576","volume":"7","author":"Iida H","year":"1987","journal-title":"J Cereb Blood Flow Metab"},{"key":"bibr-bibr5-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.21"},{"key":"bibr-bibr6-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1945.143.1.53"},{"key":"bibr-bibr7-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480290014002"},{"key":"bibr-bibr8-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101680"},{"key":"bibr-bibr9-106002809002400501","first-page":"833","volume":"29","author":"Muzic RF","year":"1988","journal-title":"J Nucl Med"},{"key":"bibr-bibr10-106002809002400501","volume-title":"SYSTAT system for statistics","author":"Wilkinson L","year":"1987"},{"key":"bibr-bibr11-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198500073-00005"},{"key":"bibr-bibr12-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582399"},{"key":"bibr-bibr13-106002809002400501","first-page":"935","volume":"44","author":"Franck G","year":"1986","journal-title":"Adv Neurol"},{"key":"bibr-bibr14-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1984.51.5.1109"},{"key":"bibr-bibr15-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1038\/331585a0"},{"key":"bibr-bibr16-106002809002400501","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7462"},{"key":"bibr-bibr17-106002809002400501","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.142.5.1027"}],"container-title":["DICP"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809002400501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809002400501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:03:36Z","timestamp":1777374216000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809002400501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1177\/106002809002400501"],"URL":"https:\/\/doi.org\/10.1177\/106002809002400501","relation":{},"ISSN":["1042-9611"],"issn-type":[{"value":"1042-9611","type":"print"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}