{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:05:20Z","timestamp":1777417520899,"version":"3.51.4"},"reference-count":68,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DICP"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p>Sulfasalazine has been used for many years in the management of ulcerative colitis. As many as 20 percent of patients treated with it experience intolerable adverse effects usually attributed to its sulfapyridine component. The other active component is 5-aminosalicylic acid (5-ASA); the only 5-ASA enema preparation currently available in the U.S. is mesalamine (Rowasa, Reid-Rowell) containing 5-ASA 4 g in 60 mL. In clinical trials, mesalamine has proved efficacious in treating refractory cases of distal ulcerative colitis, proctitis, and proctosigmoiditis. Because of its high cost compared with more conventional treatment modalities, it should be reserved for cases that are either refractory or intolerant to conventional treatment.<\/jats:p>","DOI":"10.1177\/106002809102500208","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T13:38:18Z","timestamp":1498743498000},"page":"140-145","source":"Crossref","is-referenced-by-count":1,"title":["Mesalamine in Ulcerative Colitis"],"prefix":"10.1177","volume":"25","author":[{"given":"Jill Mancini","family":"Fitzgerald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Donald","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"bibr-bibr1-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036296"},{"key":"bibr-bibr2-106002809102500208","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-1-50"},{"key":"bibr-bibr3-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1942.tb06841.x"},{"key":"bibr-bibr4-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1948.tb12083.x"},{"key":"bibr-bibr5-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)92080-9"},{"key":"bibr-bibr6-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.5.5.437"},{"key":"bibr-bibr7-106002809102500208","first-page":"135","volume":"1","author":"Misieweicz JJ","year":"1965","journal-title":"Lancet"},{"key":"bibr-bibr8-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.12.923"},{"key":"bibr-bibr9-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90831-5"},{"key":"bibr-bibr10-106002809102500208","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0022-3565(25)29238-2","volume":"181","author":"Peppercorn MA","year":"1972","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr-bibr11-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.7.632"},{"key":"bibr-bibr12-106002809102500208","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197601060-00002"},{"key":"bibr-bibr13-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012253032602"},{"key":"bibr-bibr14-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197309062891001"},{"key":"bibr-bibr15-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198202183060708"},{"key":"bibr-bibr16-106002809102500208","first-page":"1741","volume-title":"Physicians' desk reference","year":"1990","edition":"44"},{"key":"bibr-bibr17-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.12.1399"},{"key":"bibr-bibr18-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1987.tb00889.x"},{"key":"bibr-bibr19-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312464"},{"key":"bibr-bibr20-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965001"},{"key":"bibr-bibr21-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.13.4.278"},{"key":"bibr-bibr22-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(84)80015-3"},{"key":"bibr-bibr23-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)31672-5"},{"key":"bibr-bibr24-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90225-2"},{"key":"bibr-bibr25-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90684-0"},{"key":"bibr-bibr26-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(81)90087-3"},{"key":"bibr-bibr27-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90329-Y"},{"key":"bibr-bibr28-106002809102500208","doi-asserted-by":"publisher","DOI":"10.3109\/00365528609011102"},{"key":"bibr-bibr29-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312463"},{"key":"bibr-bibr30-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198710000-00009"},{"key":"bibr-bibr31-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.4.400"},{"key":"bibr-bibr32-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555391"},{"key":"bibr-bibr33-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312467"},{"key":"bibr-bibr34-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296159"},{"key":"bibr-bibr35-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90621-4"},{"key":"bibr-bibr36-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536639"},{"key":"bibr-bibr37-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92526-1"},{"key":"bibr-bibr38-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91724-0"},{"key":"bibr-bibr39-106002809102500208","first-page":"732","volume":"82","author":"Guarino J","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"bibr-bibr40-106002809102500208","first-page":"412","volume":"81","author":"Friedman LS","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"bibr-bibr41-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90569-0"},{"key":"bibr-bibr42-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198708000-00021"},{"key":"bibr-bibr43-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92526-1"},{"key":"bibr-bibr44-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90547-1"},{"key":"bibr-bibr45-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90462-8"},{"key":"bibr-bibr46-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804283181713"},{"key":"bibr-bibr47-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91386-2"},{"key":"bibr-bibr48-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.5.613"},{"key":"bibr-bibr49-106002809102500208","first-page":"1161","volume":"23","author":"Niv Y","year":"1987","journal-title":"Isr J Med Sci"},{"key":"bibr-bibr50-106002809102500208","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-785_2"},{"key":"bibr-bibr51-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.12.1081"},{"key":"bibr-bibr52-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90882-6"},{"key":"bibr-bibr53-106002809102500208","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991953"},{"key":"bibr-bibr54-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90253-8"},{"key":"bibr-bibr55-106002809102500208","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991917"},{"key":"bibr-bibr56-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90677-4"},{"key":"bibr-bibr57-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312465"},{"key":"bibr-bibr58-106002809102500208","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991929"},{"key":"bibr-bibr59-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"bibr-bibr60-106002809102500208","first-page":"15","volume":"83","author":"Habal FM","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"bibr-bibr61-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6384.23"},{"key":"bibr-bibr62-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.9.1084"},{"key":"bibr-bibr63-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90890-5"},{"key":"bibr-bibr64-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538136"},{"key":"bibr-bibr65-106002809102500208","doi-asserted-by":"publisher","DOI":"10.1159\/000199034"},{"key":"bibr-bibr66-106002809102500208","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-2-195"},{"key":"bibr-bibr67-106002809102500208","first-page":"64","volume":"83","author":"Meyers S","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"bibr-bibr68-106002809102500208","unstructured":"Cardinale V, ed. Drug topics red book. Oradell, NJ: Medical Economics, 1989: 619."}],"container-title":["DICP"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809102500208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809102500208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:05:01Z","timestamp":1777374301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809102500208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["10.1177\/106002809102500208"],"URL":"https:\/\/doi.org\/10.1177\/106002809102500208","relation":{},"ISSN":["1042-9611"],"issn-type":[{"value":"1042-9611","type":"print"}],"subject":[],"published":{"date-parts":[[1991,2]]}}}