{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:00:58Z","timestamp":1777417258739,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DICP"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p>The mechanism of an interaction between theophylline and mexiletine hydrochloride was investigated in 6 male inpatients coadministered both drugs and 16 inpatients (13 men, 3 women) administered theophylline only. Serum theophylline and mexiletine concentrations and urinary concentrations of theophylline and its metabolites were monitored. Theophylline clearance was 0.0278 \u00b1 0.0047 L\/kg\/h (mean \u00b1 SD) in patients coadministered theophylline and mexiletine and 0.0441 \u00b1 0.0096 in patients administered theophylline only (p&lt;0.05). The fractional urine contents of 1-methyluric acid and 3-methylxanthine were 18.7 \u00b1 2.5 and 12.6 \u00b1 2.1 percent in the former group and 26.5 \u00b1 6.0 and 17.1 \u00b1 2.0 percent in the latter group, respectively (p&lt;0.05). The fractional urine content of 1,3-dimethyluric acid was 51.8 \u00b1 3.2 in the former and 44.7 \u00b1 4.1 percent in the latter, respectively (p&lt;0.05). An inverse correlation was obtained between serum mexiletine concentrations and total fractional urine content of 1-methyluric acid and 3-methylxanthine (r = 0.704). These results suggest that the mechanism of an interaction between theophylline and mexiletine is an inhibition of demethylation of theophylline by mexiletine.<\/jats:p>","DOI":"10.1177\/106002809102500704","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:24:51Z","timestamp":1483687491000},"page":"727-730","source":"Crossref","is-referenced-by-count":4,"title":["Mechanism of Interaction between Theophylline and Mexiletine"],"prefix":"10.1177","volume":"25","author":[{"given":"Kazuyuki","family":"Ueno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Miyai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoichi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"bibr1-106002809102500704","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197803040-00002"},{"key":"bibr2-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70714-X"},{"key":"bibr3-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90175-3"},{"key":"bibr4-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.103"},{"key":"bibr5-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002400506"},{"key":"bibr6-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/30.2.319"},{"key":"bibr7-106002809102500704","first-page":"82","volume":"17","author":"Kubo H","year":"1978","journal-title":"Clin Chem Symp (Japan)."},{"key":"bibr8-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.3894"},{"key":"bibr9-106002809102500704","first-page":"530","volume":"25","author":"Takagi K","year":"1987","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"bibr10-106002809102500704","first-page":"588","volume":"26","author":"Imaeda N","year":"1988","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"bibr11-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1980.188"},{"key":"bibr12-106002809102500704","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0022-3565(25)30402-7","volume":"196","author":"Lohmann SM","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr13-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1177\/106002808201600504"},{"key":"bibr14-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1177\/1060028087021007-801"},{"key":"bibr15-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(81)90313-0"},{"key":"bibr16-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1982.tb01965.x"},{"key":"bibr17-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211043071906"},{"key":"bibr18-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1007\/BF00547565"},{"key":"bibr19-106002809102500704","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90178-9"}],"container-title":["DICP"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809102500704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809102500704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:13Z","timestamp":1777374253000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809102500704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":19,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1177\/106002809102500704"],"URL":"https:\/\/doi.org\/10.1177\/106002809102500704","relation":{},"ISSN":["1042-9611"],"issn-type":[{"value":"1042-9611","type":"print"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}