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IGIV preparations are approved for the treatment of hypogammaglobulinemia, recurrent bacterial infections due to B-cell chronic lymphocytic leukemia, and idiopathic thrombocytopenic purpura (ITP). The mechanism of action in the first two indications is passive replacement of antibodies, but in ITP the mechanism is not clearly established. The clinical literature on the use of IGIV for these indications is summarized. In patients with ITP, platelet counts return to safe levels and the number of infections is reduced in patients with primary humoral immunodeficiency treated with IGIV. The use of IGIV in pregnant women and premature infants is controversial. Adverse reactions are primarily related to infusion rate, activation of complement, and anaphylactic reactions to a component of the product. There is minimal to no risk of viral transmission with IGIV therapy. IGIV also has been administered safely on an outpatient or homecare basis. This has led to a feeling of greater control by patients over their chronic illness. Other uses of IGIV are under investigation. As our understanding of the immune system and the pharmacology of immune globulin increases, the uses of IGIV will expand.<\/jats:p>","DOI":"10.1177\/106002809102500717","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:24:51Z","timestamp":1483687491000},"page":"805-817","source":"Crossref","is-referenced-by-count":10,"title":["Use of Intravenous Immune Globulin Therapy: An Overview"],"prefix":"10.1177","volume":"25","author":[{"given":"Cindy J.","family":"Wordell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"bibr1-106002809102500717","unstructured":"Sell S. Immunology, immunopathology and immunity. 4th ed. 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