{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:04:18Z","timestamp":1777417458276,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DICP"],"published-print":{"date-parts":[[1991,12]]},"abstract":"\n The pharmacokinetics of gentamicin in postpartum women with endomyometritis were characterized and models for predicting patient pharmacokinetic parameters were developed using multiple regression analysis. Fifty-one women 13\u201334 years of age received gentamicin in combination with either ampicillin or clindamycin to treat endomyometritis. Forty-three women delivered by cesarean section and 8 women had vaginal deliveries. Gentamicin serum concentrations were determined at steady-state to compute the elimination rate constant (K\n e<\/jats:sub>\n ), half-life (t1\/2), apparent volume of distribution (V\n d<\/jats:sub>\n ), and total body clearance (Cl). Gentamicin dosages were individualized using a one-compartment intermittent infusion model to achieve steady-state peak and trough concentrations of 6.5 and <2 \u03bcg\/mL, respectively. The mean gentamicin t1\/2 was 2.8 \u00b1 0.9 h; the mean apparent V\n d<\/jats:sub>\n was 21 \u00b1 8 L; and the mean total body Cl was 89.5 \u00b1 31.7 mL\/min. Multiple regression analysis revealed that total body weight (TBW) was the best predictor for the apparent V\n d<\/jats:sub>\n , described by the equation V\n d<\/jats:sub>\n = 0.146 TBW + 8.153 (r=0.56, p=0.00005). Total body weight and creatinine clearance (Cl\n cr<\/jats:sub>\n ) were included as predictors for total body Cl, described by the equation Cl = 0.264 TBW + 0.337 Cl\n cr<\/jats:sub>\n + 3.416 (r=0.68, p=0.00005). Age and serum creatinine (SCr) were included in the models for the K\n e<\/jats:sub>\n , described by the equation K\n e<\/jats:sub>\n = \u22123.770 \u00b7 10\n \u22123<\/jats:sup>\n age \u2014 0.115 SCr + 0.449 (r=0.42, p<0.004). Additional patient factors need to be identified to explain the variance in these pharmacokinetic parameters.\n <\/jats:p>","DOI":"10.1177\/106002809102501203","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T23:44:10Z","timestamp":1498952650000},"page":"1306-1309","source":"Crossref","is-referenced-by-count":2,"title":["Gentamicin Pharmacokinetics in Postpartum Women with Endomyometritis"],"prefix":"10.1177","volume":"25","author":[{"given":"Myrna Y.","family":"Munar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene A.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,12,1]]},"reference":[{"key":"bibr-bibr1-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198602000-00021"},{"key":"bibr-bibr2-106002809102501203","first-page":"723","volume":"61","author":"Duff P","year":"1983","journal-title":"Obstet Gynecol"},{"key":"bibr-bibr3-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/7.3.287"},{"key":"bibr-bibr4-106002809102501203","first-page":"559","volume":"56","author":"Zaske DE","year":"1980","journal-title":"Obstet Gynecol"},{"key":"bibr-bibr5-106002809102501203","first-page":"416","volume":"3","author":"Gardner DK","year":"1984","journal-title":"Clin Pharm"},{"key":"bibr-bibr6-106002809102501203","first-page":"331","volume-title":"Applied pharmacokinetics: Principles of therapeutic drug monitoring","author":"Zaske DE","year":"1986"},{"key":"bibr-bibr7-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5906.477"},{"key":"bibr-bibr8-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1977213362"},{"key":"bibr-bibr9-106002809102501203","first-page":"353","volume":"2","author":"Torres MJ","year":"1983","journal-title":"Clin Pharm"},{"key":"bibr-bibr10-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198609000-00006"},{"key":"bibr-bibr11-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1915.00070240077005"},{"key":"bibr-bibr12-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1177\/106002807400801104"},{"key":"bibr-bibr13-106002809102501203","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"}],"container-title":["DICP"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809102501203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809102501203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:51Z","timestamp":1777374291000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809102501203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1177\/106002809102501203"],"URL":"https:\/\/doi.org\/10.1177\/106002809102501203","relation":{},"ISSN":["1042-9611"],"issn-type":[{"value":"1042-9611","type":"print"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}