{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:09:20Z","timestamp":1777417760257,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of possible association of benzalkonium chloride in nebulizer solutions with respiratory arrest and to review the involvement of various preservative agents in paradoxical bronchoconstrictive reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>Reference articles, case reports, and editorials are identified in the text.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Many pharmacologic agents are available for nebulization. In addition to the active drug, these nebulizer solutions may contain preservatives. We describe a case of respiratory arrest in a 64-year-old man following nebulization therapy with albuterol and ipratropium solutions. These solutions contain benzalkonium chloride as a preservative. We are aware of only one report describing two deaths associated with such a severe reaction attributable to nebulization therapy. However, many reports of milder paradoxical bronchoconstriction are available in the medical literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Clinicians should be aware of the possibility of paradoxical bronchoconstrictive reactions when patients are treated with nebulized bronchodilators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809202600604","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T17:49:28Z","timestamp":1484156968000},"page":"772-774","source":"Crossref","is-referenced-by-count":17,"title":["Possible Association of Benzalkonium Chloride in Nebulizer Solutions with Respiratory Arrest"],"prefix":"10.1177","volume":"26","author":[{"given":"Michel","family":"Boucher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrella T.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,6,1]]},"reference":[{"key":"bibr-bibr1-106002809202600604","first-page":"165","volume":"42","author":"Worthington I","year":"1989","journal-title":"Can J Hosp Pharm"},{"key":"bibr-bibr2-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1988.tb03305.x"},{"key":"bibr-bibr3-106002809202600604","first-page":"202","volume":"2","year":"1988","journal-title":"Lancet"},{"key":"bibr-bibr4-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92246-4"},{"key":"bibr-bibr5-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90336-9"},{"key":"bibr-bibr6-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6581.1197-a"},{"key":"bibr-bibr7-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.6.1405"},{"key":"bibr-bibr8-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03330160078030"},{"key":"bibr-bibr9-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.6.446"},{"key":"bibr-bibr10-106002809202600604","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6713.1433-a"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:05:42Z","timestamp":1777374342000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809202600604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["10.1177\/106002809202600604"],"URL":"https:\/\/doi.org\/10.1177\/106002809202600604","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}