{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:10:17Z","timestamp":1777417817305,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of mercaptopurine-induced fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A patient with Crohn's disease was treated with mercaptopurine (6-MP) for an exacerbation of his illness. The patient developed fever and chills. After thorough diagnostic examinations and failure to respond to antimicrobial therapy, symptoms were attributed to an allergic-type reaction to 6-MP. The patient defervesced after 6-MP withdrawal. Fever and chills, along with arthralgias, recurred upon rechallenge with a single dose of 6-MR<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Adverse effects attributable to 6-MP therapy in inflammatory bowel disease were reviewed in the literature. Drug-induced fever has been previously reported; however, it is an uncommon adverse effect and is difficult to diagnose. It is also difficult to predict which patients will have the reaction. It is a diagnosis of exclusion requiring a thorough investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Drug-induced fever should be considered when confronted with fever and chills in patients with inflammatory bowel disease being treated with 6-MP. This case report shows the difficulty in differentiating between an infectious process and an adverse reaction to a medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809202600707","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:41:04Z","timestamp":1483688464000},"page":"907-909","source":"Crossref","is-referenced-by-count":4,"title":["Mercaptopurine-Induced Fever in a Patient with Crohn's Disease"],"prefix":"10.1177","volume":"26","author":[{"given":"Eric L.","family":"Rehr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay A.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"bibr1-106002809202600707","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(21)00426-X"},{"key":"bibr2-106002809202600707","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92524-2"},{"key":"bibr3-106002809202600707","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-8-641"},{"key":"bibr4-106002809202600707","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005013021801"},{"key":"bibr5-106002809202600707","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198710000-00011"},{"key":"bibr6-106002809202600707","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.56.654.274"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:05:51Z","timestamp":1777374351000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809202600707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":6,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1177\/106002809202600707"],"URL":"https:\/\/doi.org\/10.1177\/106002809202600707","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}