{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:10:26Z","timestamp":1777417826141,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Because the analgesic effects of ketorolac are equivalent to those of narcotic analgesics, we investigated the possibility that this non-steroidal antiinflammatory drug might also exhibit anesthetic-sparing properties similar to those described for narcotic agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>A nonrandomized, double-blind convenience sample. The treatment group received a preoperative dose of ketorolac 60 mg im 45 minutes prior to the induction of anesthesia. All other preoperative medications were identical.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>Brooke Army Medical Center, a primary care setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS:<\/jats:title>\n                    <jats:p>Six women requiring vaginal hysterectomies from American Society of Anesthesiologists class I\/II, all of similar age, weight, and body surface area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OUTCOME MEASURES:<\/jats:title>\n                    <jats:p>End-tidal concentrations of the anesthetic gas were measured at five-minute intervals using a gas analyzer. A mean percent end-tidal concentration versus time curve was generated for each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The area under the concentration curves for the anesthetic gas in the ketorolac and control group were 15.9 \u00b1 5.1 and 52.3 \u00b1 13.4, respectively (p=0.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Ketorolac exhibits an anesthetic-sparing quality similar to that observed with narcotic analgesics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809202600712","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:41:04Z","timestamp":1483688464000},"page":"922-924","source":"Crossref","is-referenced-by-count":10,"title":["Possible Intraoperative Anesthetic-Sparing Effect of Parenteral Ketorolac"],"prefix":"10.1177","volume":"26","author":[{"given":"Jeffrey T.","family":"Moss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis L.","family":"Baysinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garry W.","family":"Boswell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samual","family":"Sayson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"bibr1-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198212000-00010"},{"key":"bibr2-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198311000-00005"},{"key":"bibr3-106002809202600712","first-page":"917","volume-title":"Anaesthesia","author":"Lictor JL","year":"1990","edition":"3"},{"key":"bibr4-106002809202600712","first-page":"479","volume":"11","author":"Rooks WH","year":"1985","journal-title":"Drug Exp Clin Res"},{"key":"bibr5-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1021\/jm00146a011"},{"key":"bibr6-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965079"},{"key":"bibr7-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60012-5"},{"key":"bibr8-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(78)90265-0"},{"key":"bibr9-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1986.tb03485.x"},{"key":"bibr10-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1987.71"},{"key":"bibr11-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1990.tb03603.x"},{"key":"bibr12-106002809202600712","first-page":"1173","volume":"43","author":"Estenne B","year":"1988","journal-title":"Curr Ther Res"},{"key":"bibr13-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb05393.x"},{"key":"bibr14-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.70"},{"key":"bibr15-106002809202600712","first-page":"197","volume":"29","author":"Roe RL","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"bibr16-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1007\/BF00558243"},{"key":"bibr17-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/63.5.601"},{"key":"bibr18-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197209282871301"},{"key":"bibr19-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1007\/BF01066064"},{"key":"bibr20-106002809202600712","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199102000-00005"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:05:52Z","timestamp":1777374352000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809202600712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":20,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1177\/106002809202600712"],"URL":"https:\/\/doi.org\/10.1177\/106002809202600712","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}