{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:11:20Z","timestamp":1777417880216,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report two cases of enhanced oral anticoagulant effect induced by doxycycline coadministration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>University teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS:<\/jats:title>\n                    <jats:p>Two patients on chronic oral anticoagulation therapy who presented with severe bleeding and marked impairment in blood coagulation tests shortly after the initiation of doxycycline therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>The literature concerning the possible effects of tetracyclines on hemostasis with or without antecedent anticoagulation therapy is reviewed and the speculated mechanisms for such an interaction are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The administration of tetracyclines such as doxycycline to patients on chronic oral anticoagulation therapy may be associated with a marked enhancement in anticoagulant effect. In such patients the prothrombin ratio should be closely monitored and the anticoagulant dosage adjusted accordingly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809202600906","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T06:35:00Z","timestamp":1484202900000},"page":"1084-1086","source":"Crossref","is-referenced-by-count":19,"title":["Enhanced Anticoagulant Effect of Coumarin Derivatives Induced by Doxycycline Coadministration"],"prefix":"10.1177","volume":"26","author":[{"given":"Yoseph","family":"Caraco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Rubinow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"bibr-bibr1-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91431-5"},{"key":"bibr-bibr2-106002809202600906","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198325060-00004"},{"key":"bibr-bibr3-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1947.02880190095027"},{"key":"bibr-bibr4-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1968.tb01512.x"},{"key":"bibr-bibr5-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1968.01330200104020"},{"key":"bibr-bibr6-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92226-2"},{"key":"bibr-bibr7-106002809202600906","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1989.tb136404.x"},{"key":"bibr-bibr8-106002809202600906","first-page":"179","volume":"1964","author":"Searcy RL","year":"1965","journal-title":"Antimicrob Agents Chemother"},{"key":"bibr-bibr9-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/73.3.439"},{"key":"bibr-bibr10-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.8.2.173"},{"key":"bibr-bibr11-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1957.00260120130015"},{"key":"bibr-bibr12-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1177\/000331976501600105"},{"key":"bibr-bibr13-106002809202600906","first-page":"1620","volume":"37","author":"Westfall LK","year":"1980","journal-title":"Am J Hosp Pharm"},{"key":"bibr-bibr14-106002809202600906","doi-asserted-by":"publisher","DOI":"10.3109\/00365516209051282"},{"key":"bibr-bibr15-106002809202600906","first-page":"503","volume":"34","author":"Remmel RP","year":"1981","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"bibr-bibr16-106002809202600906","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198815060-00001"},{"key":"bibr-bibr17-106002809202600906","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(69)90266-4"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:01Z","timestamp":1777374361000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809202600906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1177\/106002809202600906"],"URL":"https:\/\/doi.org\/10.1177\/106002809202600906","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}